Testicular involvement in pediatric lymphoid tumors: a review of the literature and a series of clinical observations
- 作者: Korneeva M.S.1, Batmanova N.A.1, Panferova T.R.1, Valiev T.T.1
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隶属关系:
- N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
- 期: 编号 1 (2024)
- 页面: 107-112
- 栏目: Clinical case
- URL: https://journals.eco-vector.com/1728-2985/article/view/630588
- DOI: https://doi.org/10.18565/urology.2024.1.107-112
- ID: 630588
如何引用文章
详细
Lymphoid tumors with testicular involvement in childhood are rare and heterogeneous. The disease may manifest with uni- or bilateral scrotal enlargement. Comprehensive examination includes evaluation of all lymph nodes involvement, as well as ultrasound examination, magnetic resonance imaging and positron emission tomography. A diagnosis is made on basis of morphological and immunohistochemical verification. Determination of lymphoid tumor variant and stage, is recommended to perform chemotherapy according to prognostic risk group, and, in some cases, transplantation of hematopoietic stem cells is required as consolidation therapy.
We present three rare clinical cases of follicular lymphoma with testicular involvement, T-lymphoblastiс progenitor cell lymphoma, and B-lineage acute lymphoblastic leukemia (ALL) relapse. Different schemes of chemotherapy, combined with orchiectomy (in 2 of 3 cases) resulted in prolonged complete remission. In the first case, due to treatment-refractory B-lineage ALL, the disease was incurable.
Our data on clinical, morphological, immunohistochemical and therapeutic features of lymphoid tumors with testicular involvement make it necessary to form multidisciplinary teams, including pediatric urologists, hematologic oncologists and surgeons for timely diagnosis and successful treatment.
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作者简介
M. Korneeva
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
编辑信件的主要联系方式.
Email: margokorneeva@mail.ru
ORCID iD: 0000-0001-9805-9972
Hematologist at the Department of Pediatric Oncology and Hematology (Chemotherapy of Hemoblastosis) No. 2 of the Research Institute of Pediatric Oncology and Hematology at N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
俄罗斯联邦, MoscowN. Batmanova
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Email: batmanova_nataly@mail.ru
ORCID iD: 0000-0002-3005-2085
Ph.D., Head of the Department of Pediatric Oncology and Hematology (Chemotherapy of Hemoblastosis) No. 2 of the Research Institute of Pediatric Oncology and Hematology at N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
俄罗斯联邦, MoscowT. Panferova
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Email: tizmailova@gmail.com
ORCID iD: 0000-0003-2240-069X
Ph.D., Senior Researcher of the Department of Radiology of the Department of Radiation Methods for the Diagnosis and Treatment of Tumors of the Research Institute of Pediatric Oncology and Hematology named after Academician of the Russian Academy of Medical Sciences L.A. Durnov at N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
俄罗斯联邦, MoscowT. Valiev
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Email: timurvaliev@mail.ru
ORCID iD: 0000-0002-1469-2365
Ph.D., MD, Head of the Department of Pediatric Oncology and Hematology (Chemotherapy of Hemoblastosis) No. 1 of the Research Institute of Pediatric Oncology and Hematology at N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
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