Revolutionizing Cancer Treatment: Unleashing the Power of Combining Oncolytic Viruses with CAR-T Cells


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Abstract

:Oncolytic Viruses (OVs) have emerged as a promising treatment option for cancer thanks to their significant research potential and encouraging results. These viruses exert a profound impact on the tumor microenvironment, making them effective against various types of cancer. In contrast, the efficacy of Chimeric antigen receptor (CAR)-T cell therapy in treating solid tumors is relatively low. The combination of OVs and CAR-T cell therapy, however, is a promising area of research. OVs play a crucial role in enhancing the tumor-suppressive microenvironment, which in turn enables CAR-T cells to function efficiently in the context of solid malignancies. This review aims to provide a comprehensive analysis of the benefits and drawbacks of OV therapy and CAR-T cell therapy, with a focus on the potential of combining these two treatment approaches.

About the authors

Lin Zhang

Department of Dermatology, Affiliated Hospital of Xuzhou Medical University

Email: info@benthamscience.net

ShuXian Guo

Department of Dermatology, Affiliated Hospital of Xuzhou Medical University

Email: info@benthamscience.net

ShuYing Chang

Department of Dermatology, Affiliated Hospital of Xuzhou Medical University

Email: info@benthamscience.net

Guan Jiang

Department of Dermatology, Affiliated Hospital of Xuzhou Medical University

Author for correspondence.
Email: info@benthamscience.net

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