Evaluation of the temperature influence effect on stability and particle size of niosomal dispersions based on PEG-12 dimethicone

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Abstract

In this paper, the dynamics of changes in the ζ potential and particle sizes of niosomal dispersions of various concentrations under temperature variation is studied by the method of dynamic light scattering. The average diameter changes of the niosomes and the polydispersity index were revealed. The most significant influence of temperature on the considered parameters was observed in the interval 303–313 K. The experimental data indicated an increase in the zeta potential with increasing temperature. Based on the analysis performed, possibility of increasing the niosomal dispersions stability by means of temperature influence was confirmed.

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About the authors

E. I. Diskaeva

Stavropol State Medical University

Author for correspondence.
Email: e_diskaeva@mail.ru
ORCID iD: 0000-0002-6095-7010

Cand. of Sci. (Physics and Mathematics), Docent

Russian Federation, Stavropol

O. V. Vecher

Stavropol State Medical University

Email: e_diskaeva@mail.ru
ORCID iD: 0000-0002-6743-874X

Cand. of Sci. (Physics and Mathematics), Docent

Russian Federation, Stavropol

I. A. Bazikov

Stavropol State Medical University

Email: e_diskaeva@mail.ru
ORCID iD: 0000-0001-9207-6552

Doct. of Sci. (Medicine), Prof., Head of Department

Russian Federation, Stavropol

E. N. Diskaeva

Branch of RTU MIREA

Email: e_diskaeva@mail.ru
ORCID iD: 0000-0002-5185-6023

Cand. of Sci. (Physics and Mathematics), Docent

Russian Federation, Stavropol

K. S. Elbekyan

Stavropol State Medical University

Email: e_diskaeva@mail.ru
ORCID iD: 0000-0003-2403-8663

Doct. of Sci. (Biology), Prof., Head of Department

Russian Federation, Stavropol

E. S. Lopatina

Stavropol State Medical University

Email: e_diskaeva@mail.ru
ORCID iD: 0009-0006-9963-6739

Assistant

Russian Federation, Stavropol

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2. Fig.1. Temperature dependence of ζ potential of niosomal dispersions

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Copyright (c) 2025 Diskaeva E.I., Vecher O.V., Bazikov I.A., Diskaeva E.N., Elbekyan K.S., Lopatina E.S.