Hepato-pulmonary syndrome: issues of pathogenesis, diagnostics and treatment


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The basis of hepato-pulmonary syndrome (HPS) in patients with chronic liver disease is intrapulmonary vasodilatation breaking arterial oxygenation. The concerns for pathophysiology, diagnosis and treatment of this pathology are discussed. There are many techniques such as contrast echocardiography and standard cardiopulmonary test for HPS diagnosis. Treatment of this condition consists in oxygen therapy and orthotopic liver transplantation, in severe hypoxemia especially.

参考

  1. Schenk P, Schoniger-Hekele M, Fuhrmann V, et al. Prognostic significance of the hepatopulmonary syndrome in patients with cirrhosis. Gastroenterol 2003;125:1042-52.
  2. Palma D, Fallon M. The hepatopulmonary syndrome. J Hepatology 2006;45:617-25.
  3. Rodrigues-Rosin R, Krowka MJ, Herve P, et al. On behalf of the ERS Task Force Pulmonary-Hepatic Vascular Disorders Scientific Committee ERS Task Force PHD Scientific Committee. Pulmonary-Hepatic vascular Disorders (PHD). Eur Respir J 2004;24:861-80.
  4. Martinez G, Barbera J, Visa J, et al. Hepatopulmonary syndrome in candidates for liver transplantation. J Hepatology 2001;34:756-58.
  5. Regev A, Yeshurun M, Rodriguez M, et al. Transient hepatopulmonary syndrome in a patient with acute hepatitis A. J Viral Hep 2001;8:83-86.
  6. Teuber G, Teupe C, Dietrich C, et al. Pulmonary dysfunction in non-cirrhotic patients with chronic viral hepatitis. Eur J Intern Med 2002;13:311-18.
  7. Gomez F, Barbera J, Roca J, et al. Effects of nebulized NG-nitro-L-arginine methyl ester in patients with hepatopulmonary syndrome. Hepatology 2006;43:1084-91.
  8. Brussino L, Bucca C, Morello M, et al. Effect on dyspnoea and hypoxaemia of inhaled NG-nitro-L-arginine methyl ester in hepatopulmonary syndrome. Lancet 2003;362:43-44.
  9. Arguedas MR, Drake BB, Kapoor A, et al. Carboxyhemoglobin levels in cirrhotic patients with and without hepatopulmonary syndrome. Gastroenterol 2005;128:328-33.
  10. Luo B, Liu L, Tang L, et al. ET-1 and TNF-{alpha} in HPS: analysis in prehepatic portal hypertension and biliary and nonbiliary cirrhosis in rats. Am J Physiol Gastrointest Liver Physiol 2004;286:G294-G303.
  11. Zhang J, Ling Y, Luo B, et al. Analysis of pulmonary heme oxygenase-1 and nitric oxide synthase alterations in experimental hepatopulmonary syndrome. Gastroenterol 2003;125:1441-51.
  12. Luo B, Liu L, Tang L, et al. Increased pulmonary vascular endothelin B receptor expression and responsiveness to endothelin-1 in cirrhotic and portal hypertensive rats: a potential mechanism in experimental hepatopulmonary syndrome. J Hepatol 2003;38:556-63.
  13. Ling Y, Zhang J, Luo B, et al. The role of endothelin-1 and the endothelin B receptor in the pathogenesis of experimental hepatopulmonary syndrome. Hepatology 2004;39:1593-602.
  14. Luo B, Tang L, Wang Z, et al. Cholangiocyte endothelin-1 and transforming growth factor-beta1 production in rat experimental hepatopulmonary syndrome. Gastroenterol 2005;129:682-95.
  15. Sztrymf B, Rabiller A, Nunes H, et al. Prevention of hepatopulmonare syndrome by pentoxifylline in cirrhotic rats. Eur Respir J 2004;23:752-58.
  16. Gomez F, Martinez-Palli G, Barbera J, et al. Gas exchange mechanism of orthodeoxia in hepatopulmonary syndrome. Hepatology 2004;40:660-66.
  17. Arguedas M, Abrams GA, Krowka MJ, et al. Prospective evaluation of outcomes and predictors of mortality in patients with hepatopulmonary syndrome undergoing liver transplantation. Hepatology 2003;37:192-97.
  18. Abrams G, Nanda N, Dubovsky E, et al. Use of macroaggregated albumin lung perfusion scan to diagnose hepatopulmonary syndrome: a new approach. Gastroenterol 1998:114.
  19. Krowka MJ, Dickson ER, Cortese DA. Hepatopulmonary syndrome. Clinical observation and lack of therapeutic response to somatostatin analogue. Chest 1993;104:515-21.
  20. Lima BL, Franca AV, Pazin-Filho A, et al. Frequency, clinical characteristics, and respiratory parameters of hepatopulmonary syndrome. Mayo Clin Proc 2004;79-42.
  21. Lee KN, Lee HJ, Shin WW, et al. Hypoxemia and liver cirrhosis (hepatopulmonary syndrome) in eight patients: comparison of the central and peripheral pulmonary vasculature. Radiology 1999;211:549-53.
  22. Katsuta Y, Honma H, Zhang X, et al. Pulmonary blood transit time and impaired arterial oxygenation in patients with chronic liver disease. J Gastroenterol 2005;40:57-63.
  23. Swanson KL, Wiesner RH, Kwowka MJ. Natural history of hepatopulmonary syndrome: impact of liver transplantation. Hepatology 2005;41:1122-29.
  24. Javaheri S, Almoosa KF, Saleh K, et al. Hypocapnia is not a predictor of central sleep apnea in patients with cirrhosis. Am J Respir Crit Care Med 2005;171:908-11.
  25. Martinez-Palli G, Barbera JA, Taura P, et al. Severe portopulmonary hypertension after liver transplantation in a patient with preexisting hepatopulmonary syndrome. J Hepatol 1999;331:1075-79.
  26. Philit F, Wiesendanger T, Gille D, et al. Late resolution of hepatopulmonary syndrome after liver transplantation. Respiration 1997;6:173-75.
  27. Durand P, Baujard C, Grosse AL. Reversal of hypoxemia by inhaled nitric oxide in children with severe hepatopulmonary syndrome, type 1, during and after liver transplantation. Transplantation 1998;65:437-39.
  28. Sulieman B, Voigt M, Kats D, et al. Data driven policy for points allocation in hepatopulmonary syndrome. Hepatology 2005;42:347.
  29. Henrinon J, Schapira M, Luwaert R, et al. Hypoxic hepatitis: clinical and hemodynamic study in 142 consecutive cases. Medicine (Baltimore) 2003;82:392-406.
  30. Riegler JL, Lang KA, Johnson SP, et al. Transjugular intrahepatic portosystemic shunt improves oxygenation in hepatopulmonary syndrome. Gastroenterol 1995;109:978-83.
  31. Selim KM, Akriviadis EA, Zuckerman E, et al. Transjugular intrahepatic portosystemic shunt: a successful treatment for hepatopulmonary syndrome. Am J Gastroenterol 1998;93:455-58.
  32. Allgaier HP, Haag K, Ochs A, et al. Hepatopulmonary syndrome: successful treatment by transjugular intrahepatic portosystemic stent-shunt (TIPS). J Hepatol 1995;23:102-105.
  33. Paramesh A, Hussain S, Shneider B, et al. Improvement of hepatopulmonary syndrome after transjugular intrahepatic portosystemic shunting: case report and review of literature. Pediatr Transplant 2003;7:157-62.
  34. Chevallier P, Novelli L, Motamedi JP, et al. Hepatopulmonary syndrome successfully treated with transjugular intrahepatic portosystemic shunt: a three-year follow-up. J Vasc Interv Radiol 2004;15:647-48.
  35. Corley DA, Scharschmidt B, Bass N, et al. Lack of efficacy of TIPS for hepatopulmonary syndrome. Gastroenterol 1997;113:728-31.
  36. Abrams GA, Fallon M. The hepatopulmonary syndrome. Clin Liver Dis 1997;1:185-200.
  37. Abrams GA, Fallon MB. Treatment of hepatopulmonary syndrome with Allium sativum (garlic): a pilot trial. J Clin Gastroenterol 1998;27:232-35.
  38. Brussino L, Bucca C, Morello M, et al. Effect on dyspnoea and hypoxemia of inhaled NG-nitro-L-arginine methyl ester in hepatopulmonary syndrome. Lancet 2003;362:43-44.
  39. Anel RM, Sheagren JN. Novel presentation and approach to management of hepatopulmonary syndrome with use of antimicrobial agents. Clin Infect Dis 2001;32:E131-E136.

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