Carbamazepine and oxcarbazepine: results and prospects for use in epileptology


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Abstract

The article discuss problem of treatment of epilepsy by modern antiepileptic drugs (AED), taking into account the therapy effectiveness, development of adverse effects and costs of treatment. Based on the analysis of antiepileptic therapy in an adult population with epilepsy of Samara region, as well as own study, including 15 patients with epilepsy, the authors concludes that until recently carbamazepine occupied the leading place due to cost-benefit ratio, and in recent time oxcarbazepine is alternative drug, because it not only has the clinical efficacy and moderate cost, but also well tolerated by patients.

References

  1. Белоусов Ю.Б., Белоусов Д.Ю., Чикина Е.С. и др. Исследование медико-социальных проблем эпилепсии в России // Качественная клиническая практика. 2004. № 4. С. 78-79.
  2. Вейн А.М., Воробьева О.В. Оптимизация тактики терапии симптоматических парциальных эпилепсий с использованием ретардной формы карбамазепина. В кн.: EPI'2000 II Восточноевропейская конференция "Эпилепсия и клиническая нейрофизиология", Крым, Гурзуф. 2000. С. 193-194.
  3. Гехт А.Б., Мильчакова Л.Е., Чурилин Ю.Ю. и др. Эпидемиология эпилепсии в России // Журнал неврологии и психиатрии. 2006. Т. 106. № 1. С. 3-7.
  4. Вольф К. Медикаментозное лечение эпилепсии / В кн.: Диагностика и лечение эпилепсий у детей. М., 1997. С. 581-531.
  5. Зенков Л.Р. Фармакологическое лечение эпилепсии // РМЖ. 2000. Т. 8. № 10. С. 411-417.
  6. Зенков Л.Р. Роль окскарбазепина в терапии эпилепсии // Consilium medicum. 2005. Т. 7. № 8. С. 710-714.
  7. Мухин К.Ю., Петрухин А.С. Эпилептические синдромы. Диагностика и стандарты терапии. М., 2005. 143 с.
  8. "Розничный аудит ГЛС в РФ®" и "Анализ госпитальных закупок ГЛС в РФ®". - www.RMBC.ru, 2004.
  9. Albani F, Grassi B, Ferrara R, et al. Immediate (overnight) switching from carbamazepine monotherapy is equivalent to a progressive switch. Seizure 2004;13:254-63.
  10. Bang LM, Goa KL. Oxcarbazepine. A review of its use in childern with epilepsy. Pediatr Drugs 2003;5:557-73.
  11. Bang LM, Goa KL. Spotlight on oxcarbazepine in epilepsy. CNS Drugs 2004;18:57-61.
  12. Beydoun A, Sachdeo RC, Rosenfeld WE, et al. Oxcarbazepine monotherapy for partial-onset seizures: a multicenter, double-blind, clinical trial. Neurology 2000;54:2245-51.
  13. Brodie MJ, Dicher MA. Antiepileptic drugs. N Engl J Med 1996;334:168-75.
  14. Clemens B, Menes A, Nagy Z. Objective assessment of neurotoxicity while shifting from carbamazepine to oxcarbazepine. Acta Neurol Scand 2004;109:324-29.
  15. French JA, Kanner AM, Bautista J, et al. Efficacy and tolerability of the new antiepileptic drugs I: Treatment of new onset epilepsy: Report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology 2004;62:1252-60.
  16. French JA, Kanner AM, Bautista J, et al. Efficacy and tolerability of the new antiepileptic drugs, II: Treatment of refractory epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society. Epilepsia 2004;45:410-23.
  17. Heller AJ, Chesterman P, Elwes RDC, et al. Phenobarbitone, phenitoin, carbamazepine, or sodium valproate for newly diagnosed adult epilepsy: a randomized comparative monоtherapy trial. J Neurology Neurosurg Psychiatr 1995;58:44-50.
  18. Homberg V, Kowalik A, Schulze-Bonhage A. Ad hoc change from carbamazepine to oxcarbazepine - effectiveness and tolerance. A retrospective analysis. Nervenarzt 2001;72:918-23.
  19. Oxcarbazepine: new preparation. An alternative to carbamazepine in partial epilepsy. Prescrire Int 2001;10:170-74.
  20. Ryan SW, Forsyth I, Hartley R, et al. Slow release carbamazepine in treatment of poorly controlled seizures. Arch Dis Child 1990;65:930-35.
  21. Sachdeo R, Beydoun A, Schachter S, et al. Oxcarbazepine (Trileptal) as monotherapy in patients with partial seizures. Neurology 2001;57:864-71.
  22. Sallas WM, Milosavljev S, D'souza J, et al. Pharmacokinetic drug interactions in children taking oxcarbazepine. Clin Pharmacol Ther 2003;74:138-49.
  23. Schachter SC, Vazquez B, Fisher RS, et al. Oxcarbazepine: double-blind, randomized, placebo-control, monotherapy trial for partial seizures. Neurology 1999;52:732-37.
  24. Vazquez B. Monotherapy in Epilepsy. Role of the Newer Antiepileptic Drugs. Arch Neurol 2004;61:1361-65.
  25. Wellington K, Goa KL. Oxcarbazepine: an update of its efficay in the management of epilepsy. CNS Drugs 2001;15:137-63.
  26. Wolf P. Determinants of outcome in childhood epilepsy. Acta Neurol Scand 2005;112(Suppl. 182):5-8

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