Evaluation of nootropics action efficacy in patients with asthenic disturbances with the use of electroencephalographic method


Cite item

Full Text

Abstract

The article highlights the results of electroencephalographic (EEG) analysis of the nootropic drugs (Nooklerin and Fenotropil®) efficacy in asthenic disorders. EEG profiles of the investigated drugs are established. Correlation and discriminant analyses identified prognostic spectral characteristics for the effectiveness of course treatment by nootropics. The comparative characteristic of informative indicators of baseline EEG and the changes in the initial phase of therapy are presented.

About the authors

V K Bochkarev

V K Bochkarev

References

  1. Воронина Т.А., Середенин С.Б. Ноотропные препараты, достижения и новые проблемы // Экспериментальная и клиническая фармакология. 1998. Т. 61. № 4. С. 3-9.
  2. Изнак А.Ф. Нейрональная пластичность как один из аспектов патогенеза и терапии аффективных расстройств // Психиатрия и психофармакотерапия. 2003. Т. 5. № 1.
  3. Панюшкина С.В., Аведисова А.С. Изменение узкополосных составляющих спектра ЭЭГ при действии ноотропов // Экспериментальная и клиническая фармакология. 1992. № 3. С. 14-17.
  4. Aberg ND, Bryve KG, Isgaard J. Aspects of growth hormone and insulin-like growth factor-I related to neuroprotection, regeneration and functional plasticity in the adult brain. Scientific World J 2006;6:53-80.
  5. Alvarez XA, Mouzo R, Pichel V, et al. Double-blind placebo-controlled study with citicoline in APOE genotyped Alzheimer's disease patients. Effects on cognitive performance, brain bioelectrical activity and cerebral perfusion. Methods Find Exp Clin Pharmacol 1999;21(9):633-44.
  6. Duman RS. Neural plasticity: consequences of stress and actions of antidepressant treatment. Dialog Clin Neurosci 2004;6(2):157-69.
  7. Franco-Maside A, Caamano J, Gomez MJ, et al. Brain mapping activity and mental performance after chronic treatment with CDP-choline in Alzheimer's disease. Methods Find Exp Clin Pharmacol 1994;16(8):597-607.
  8. Herrman WM. Classification of psychopharmaca in clinical-pharmacological experiments. Advances in Pharmaco-EEG. Ed. Krijzer F., Herrmann W.M. IPEG, 1996:85-106.
  9. Itil TM. Quantitative pharmaco-electroencephalography. Use of computerized cerebral biopotentials in psychotropic drug research. Psychotropic Drugs and the Human EEG. Modern Problems of Pharmacopsychiatry. Ed. Itil T.M. Basel: Karger, 1974:43-75.
  10. Itil TM. The significance of quantitative pharmaco-EEG in the diskovery and classification of psychotropic drugs. EEG in drug research. Ed. Herrmann W.M. Stuttgart, New York: Fischer 1982:131-57.
  11. Itil T, Martorano D. Natural substances in psychiatry (ginkgo biloba in dementia). Psychopharmacol Bull 1995;31(1):147-58.
  12. Itil TM, Erlap E, Tsambis E, et al. Central nervous system effects of ginkgo biloba, a plant extract. Am J Ther 1996;3:63-73.
  13. Itil TM, Eralp E, Ahmed I, et al. The pharmacological effects of ginkgo biloba, a plant extract, on the brain of dementia patients in comparison with tacrine. Psychopharmacol Bull 1998;34(3):391-97.
  14. Jelic V, Dierks T, Amberla K, et al. Longitudinal changes in quantitative EEG during long-term tacrine treatment of patients with Alzheimer's disease. Neurosci Lett 1998;254(2):85-88.
  15. Nordberg A, Amberla K, Shigeta M, et al. Long-term tacrine treatment in three mild Alzheimer patients: effects on nicotinic receptors, cerebral blood flow, glucose metabolism, EEG, and cognitive abilities. Alzheimer Dis Assoc Disord 1998;12(3):228-37.
  16. Perryman KM, Fitten LJ. Quantitative EEG during a double-blind trial of THA and lecithin in patients with Alzheimer's disease. J Geriatr Psychiatry Neurol 1991;4(3):127-33.
  17. Pierlovisi-Lavaivre M, Michel B, Sebban C, et al. The significance of quantified EEG in Alzheimer's disease. Changes induced by piracetam. Neurophysiol Clin 1991;21(5-6):411-23.
  18. Saletu B. Pharmacodynamics and EEG. Advances in Pharmaco-EEG. Ed. Krijzer F., Herrmann W.M. PEG 1996:187-204.
  19. Saletu B, Paulus E, Linzmayer L, et al. Nicergoline in senile dementia of Alzheimer type and multi-infarct dementia: a double-blind, placebo-controlled, clinical and EEG/ERP mapping study. Psychopharmacology (Berl) 1995;117(4):385-95.
  20. Shigeta M, Persson A, Viitanen M, et al. EEG regional changes during long-term treatment with tetrahydroaminoacridine (THA) in Alzheimer's disease. Acta Neurol Scand 1993;149(Suppl.):58-61.

Supplementary files

Supplementary Files
Action
1. JATS XML

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies