Thiazide diuretics and arterial hypertension: the history is going on


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The present article is concerned with indications and contraindications to the use of thiazide diuretics (TD) such as hydrochlorothiazide, in the treatment of arterial hypertension (AH). The mechanism of action of the TD are considered, the results of major clinical trials with their use are presented. Authors discuss possible restrictions on the administration of TD in AH. Problem of type 2 diabetes mellitus associated with the use of TD, and the indications for the use of TD in AH are in the focus. It is emphasized that hydrochlorothiazide is one of the several antihypertensive drugs, which can be used for long-term treatment of AH, and for the relief of hypertensive crisis.

参考

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