Lisinopril in the treatment of arterial hypertension in patients with concomitant liver pathology


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Lisinopril is one of the most famous and well-studied angiotensin-converting enzyme (ACE) inhibitor, considered as drug-prototype. Like other members of this group, the main mechanism of action of lisinopril is founded on the blockade of active Zinc-containing domain of ACE that leads to a decrease in the synthesis of angiotensin II and activity of the renin-angiotensin-aldosterone system (RAAS) in general. This effect defines the main indications for use of ACE inhibitors. They are used for conditions in the pathogenesis of which may play a role of RAAS activation, including arterial hypertension. The article is dedicated to the basic pharmacokinetic properties of lisinopril compared with ACE inhibitors. The antihypertensive efficacy of lisinopril as monotherapy and in the combination with other drugs is considered. The available data for the use of this drug in patients with chronic hepatic disorders are analyzed.

参考

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