Aztreonam: pharmacological properties and experience of clinical use of monobactame antibiotic


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Abstract

Aztreonam is monobaktam, antibiotic with selective bactericidal action in regard to aerobic gram-negative bacteria. The spectrum of activity includes such problematic pathogens as Pseudomonas aeruginosa and Klebsiella spp. Synergy of action with antibiotics of other groups is the specific characteristic of aztreonam. Clinical efficacy of aztreonam is well studied. Monobaktam has been successfully used in the treatment of moderate and severe gram-negative infections, including infections of the CNS, respiratory tract, abdominal space, kidney and urinary tract infections, infections of soft tissues, febrile neutropenia, and others. The possibility of use of aztreonam in patients with allergy to other β-lactams (penicillins, cephalosporins) is emphasized, as well as good tolerability in adults and children with minimal risk of adverse drug reactions. Since 2009, aztreonam (invented name Aztreabol) is available in Russia.

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A A Mukonin

A Mukonin

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