POTENTIAL FOR USE OF DIET THERAPY FOR REDUCTION OF THE CARDIOVASCULAR RISK


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The present article is concerned with summary of international studies aimed to evaluation of the impact of products enriched with plant sterols and stanols on the levels of total cholesterol and low density lipoprotein. The data for efficacy and safety of long-term daily consumption of fermented dairy product Danacor are presented. It is shown that Danacor enriched in plant sterols Phytonaturalis is a useful product for everyday consumption that can lead to decrease of blood cholesterol and low density lipoproteins levels, and therefore to reduction of the cardiovascular risk and severe complications of cardiovascular diseases.

Bibliografia

  1. Демографический ежегодник России 2008. М., 557 с.
  2. World Health Organization. World Health Report 2002: Reducing risks, Promoting healthy life. Geneva: W.H.O; 2002.
  3. Диагностика и коррекция нарушений липидного обмена с целью профилактики и лечения атеросклероза. Российские рекомендации. Комитет экспертов Всероссийского научного общества кардиологов // Кардиоваскулярная терапия и профилактика, 2004. № 2 (приложение). 35 с.
  4. Von Bergmann K, Prange W, Lutjohann D. Metabolism and mechanism of action of plant sterols. Eur Heart J 1999;1(Suppl. S):S45-S49.
  5. Nguyen TT. The cholesterol-lowering action of plant stanol esters. J Nutr 1999;129(12):117-18.
  6. McKay DA. Stress, Illness and the Physician. Arch Fam Med 1998;4:497-98.
  7. Dhabhar FS. Effects of stress on immune cell distribution. J Immunol 1995;154:5511-27.
  8. Cohen S. Psychological stress and susceptibility to the common cold. New Engl J Med 1991;325:606-12.
  9. Bouic PJD, Etsebeth S, Liebenberg RW, et al. Immunomodulatory effects of B-sitosterol and B-sitosterol glucoside on human peripheral blood lymphocytes in vitro. Intern J Immunopharmacol 1996;18:693-700.
  10. Breen EC, et al. Infection with HIV is associated with elevated IL6 levels and production. J Immunol 1990;144:480-84.
  11. Newberne PM. Dietary fat, immunological response and cancer in rats. Cancer Research 1981;41:3783-85.
  12. Yamada H, et al. Effects of phytosterols on anticomplementary activity. Chemical Pharmacy Bulletin 1987;35(12):4851-55.
  13. Weihrauch JL, Gardner JM. Sterol content of foods of plant orign. J Am Diet Assoc 1978;73:39-47.
  14. Ostlund RE Jr, Racette SB, Okeke A, et al. Phytosterols that are naturally present in commercial corn oil significantly reduce cholesterol absorption in humans. Am J Clin Nutr 2002;75:1000-04.
  15. Thompson GR, Grundy SM. History and development of plant sterol and stanol esters for cholesterol-lowering purposes. Am J Cardiol 2005;1A:3D-9D.
  16. Cleghorn CL, Skeaf CM, Mann J, et al. Plant sterol-enriched spread enhances the cholesterol-lowering potential of a fat-reduced diet. Eur J Clin Nutr 2003;57:170-76.
  17. Devaraj Sjialal I, Vega-Lopez S. Plant sterol-fortified orange juice effectively lowers cholesterol levels in midly hypercholesterolaemic health individuals. Arteriosder Thromb Vase Biol 2004;24:e25-e28.
  18. Hayes KC, Pronczuk A, Perlman D. Nonesterified phytosterols dissolved and recrystallized in oil reduce plasma cholesterol in gerbils and humans. J Nutr 2004;134:1395-9.
  19. Lamarche B, Desroches S, Jenkins DJ, et al. Combined effect of dietary portfolio of plant sterols, vegetable protein, viscous fibre and almonds on LDL particle size. Br J Nutr 2004;92:657-63.
  20. Hyan YJ, Kim OY, Kang JB, et al. Plant stanol esters in low-fat yoghurt reduces total and low-density lipoprotein oxidation in normocholesterolaemic and mildly hypercholesterolaemic subjects. Nitritional Research 2006;25:743-53.
  21. Noakes M, Clifton PM, Doornbos AM, et al. Plant sterol ester-enriched milk and yoghurt effectively reduce serum cholesterol in modestly hypercholesterolaemic subjects. Eur J Nutr 2005;44:214-22.
  22. Charest A, Vanstone C, St-Onge MR, et al. Phytosterols in nonfat and low-fat beverages have no impact on the LDL size phenotype. Eur J Clin Nutr 2005;59:801-4.
  23. Jauhiainen T, Salo R, Niittynen L, et al. Effects of low-fat hard cheese enriched with plant stanol esters on serum lipids and apolipoprotein B in mildly hypercholesterolaemic subjects. Eur J Clin Nutr 2006;83:1199-203.
  24. Korpela R, Tuomilehto J, Hogstrom R, et al. Safety aspects and cholesterol-lowering efficacy of low fat dairy products containing plant sterol. Eur J Clin Nutr 2006;60:633-42.
  25. Doornbos AM, Meynen EM, Duchateau GS, et al. Intake occasion affects the serum cholesterol lowering of a plant sterol-enriched single-dose yoghurt drink in mildly hypercholesterlaemic subjects. Eur J Clin Nutr 2006;60:325-33.
  26. Blair SN, Cappuzzi DM, Gottlieb SO, et al. Incremental reduction of serum total cholesterol and low-density lipoprotein cholesterol with the addition of plant stanol ester-containing spread to statin therapy. Am J Cardiol 2000;86:46-52.
  27. Miettinen TA, Vuoristo M, Nissinen M, et al. Serum, biliary and fecal cholesterol and plant sterols in colectomized patients before and during consumption of stanol ester margarine. Am J Clin Nutr 2000;71:1095-102.
  28. Nigon F, Serfaty-Lacrosniere C, Beucler I, et al. Plant sterol-enriched margarine lowers plasma LDL in hyperlipidemic subjects with low cholesterol intake: effect of fibrate treatment. Clin Chem Lab Med 2001;39:634-40.
  29. Neil HA, Meijer GW, Roe LS. Randomised controlled trial of use by hypercholesterolaemic patients of a vegetable oil sterol-enriched fat spread. Atherosclerosis 2001;156:329-37.
  30. Simons LA. Additive effect of plant sterol-ester margarine and cervastatin in lowering low-density lipoprotein cholesterol in primary hypercholesterolemia. Am J Cardiol 2002;90:737-40.
  31. Gyllig H, Miettinen TA. LDL cholesterol lowering by bile acid malabsorbtion during inhibited synthesis and absorbtion of cholesterol in hypercholesterolemic coronary subjects. Nutr Metab Cardiovasc Dis 2002;12:19-23.
  32. Hansel B, Nicolle C, Lalanne F, et al. Effect of low-fat, fermented milk enriched with plant sterol on serum lipid profile and oxidative stress in moderate hypercholesterolemia. Am J Clin Nutr 2007;86:790-6.
  33. Hendriks HF, Brink EJ, Meijer GW, et al. Safety of long-term consumption of plant sterol esters-enriched spread. Eur J Clin Nutr 2003;57:681-92.
  34. Christiansen L, Karjalainen M, Serimaa R, et al. Phase behavior of sitosterol-cholesterol and sitistanol-cholesterol co-precipitates. STP Pharm Sci 2001;II:167-73.
  35. Hendriks HF, Weststrate JA, Van VT, et al. Spreads enriched with three different levels of vegetable oil sterols and the degree of cholesterol lowering in normocholesterolaemic and mildly hypercholesterolaemic subjects. Eur J Clin Nutr 1999;53:319-27.
  36. Hendriks HF, Ntanios F, Brink EJ, et al. One-year Follow-up study on the use of a low fat spread enriched with plant sterol-esters. Ann Nutr Metab 2006.
  37. Noakes M, Clifton R, Ntanios F, et al. An increase in dietary carotenoids when consuming plant sterols or stands is effective in maintaining plasma carotenoid concentrations. Am J Clin Nutr 2002;75:79-86.
  38. Погожаева А.В., Перова Н.В., Дербенева С.А. Оценка эффективности продукта, обогащенного фитостеринами, для коррекции гиперхолестеринемии // Consilium Medicum. 2008. Т. 10. № 11. С. 103-8.
  39. Перова Н.В., Метельская В.А. Растительные стерины и станолы в роли пищевых факторов, снижающих гиперхолестеринемию путем ингибирования всасывания холестерина в кишечнике // Кардиология. 2008. № 5. С. 63-67.
  40. A randomized, double-blind, placebo-controlled parallel-group clinical study on the effects of a fermented dairy product enriched with phytosterols over blood cholesterol levels of hypercholesterolaemic adult subjects. Danone Internal Data, 2006.
  41. Оганов Р.Г., Перова Н.В., Марцевич С.Ю. Клиническое исследование "функционального" кисло-молочного продукта питания, обогащенного растительными стеринами // Consilium Medicum. 2008. Т. 10. № 5. С. 158-163.

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