WHETHER EVIDENCES OF EFFICIENCY OF CALCIUM AND VITAMIN D IN THE PREVENTION OF OSTEOPOROTIC FRACTURES ARE STILL NECESSARY?


Cite item

Full Text

Abstract

The article discusses the role of vitamin D and calcium deficiency in the pathogenesis of osteoporotic fractures. The results of randomized clinical trials, meta-analyses and systematic reviews clearly demonstrate the efficacy of a combination of vitamin D and calcium in the prevention of nonvertebral fracture, including femoral fracture. It is emphasized that the use of high-dose of vitamin D (700 - 1000 IU/day) leads to its optimal concentration in the blood serum at level of 90 - 100 nmol/L. For the purpose of improvement of treatment compliance, drug containing 1000 mg of calcium and 800 IU of vitamin D may be used once daily.

References

  1. Brennan SJ, Johansen A, Butler J, et al. Place of residence and risk of fracture in older people: a population-based study of over 65-year-olds in Cardiff. Osteoporos Int 2003;14:515-9.
  2. Aspray TJ, Stevenson P, Abdy SE, et al. Low bone mineral density measurements in care home residents - a treatable cause of fractures. Age Ageing 2006;35:37-41.
  3. Holick MF. Vitamin D deficiency. N Engl J Med 2007;357:266-81.
  4. Hirani V, Primatesta P. Vitamin D concentrations among people aged 65 years and over living in private households and institutions in England: population survey. Age Ageing 2005;34:485-91.
  5. Lips P. Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev 2001;22:477-501.
  6. Resch H, Walliser J, Phillips S, et al. Physician and patient perceptions on the use of vitamin D and calcium in osteoporosis treatment: a European and Latin American perspective. Current Medical Research and Opinion 2007;23:1227-37.
  7. Rizzoli R, Boonen S, Brandi ML, et al. The role of calcium and vitamin D in the management of osteoporosis. Bone 2008;42:246-9.
  8. Ringe JD, van der Geest SAP, Moller G. Importance of Calcium Co-Medication in Bisphosphonate Therapy of Osteoporosis. Original Research Article 2006;23(7):569-78.
  9. Ringe JD, Fardellone P, Kruse HP, et al. Value of a New Fixed-Combination Pack of Bisphosphonate, Calcium and Vitamin D in the Therapy of Osteoporosis. Original Research Article 2009;26:241-53.
  10. Chapuy MC, Arlot ME, Duboeuf F, et al. Vitamin D3 and calcium to prevent hip fractures in the elderly women. N Engl J Med 1992;327:1637-42.
  11. Francis RM, Anderson FH, Patel S, et al. Calcium and vitamin D in the prevention of osteoporotic fractures. QJM 2006;99:355-563.
  12. Bischoff-Ferrari HA, Willett WC, Wong JB, et al. Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA 2005;293:2257-64.
  13. Bischoff-Ferrari HA, Dawson-Hughes B, Willett CW, et al. Effect of vitamin D on falls: a meta-analysis. JAMA 2004;291:1999-2006.
  14. Pfeifer M, Begerow B, Minne HW, et al. Effects of a short-term vitamin D and calcium supplementation on body sway and secondary hyperparathyroidism in elderly women. J Bone Miner Res 2000;15:1113-8.
  15. Bischoff HA, Stahelin HB, Dick W, et al. Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial. J Bone Miner Res 2003;18:343-51.
  16. Boonen S, Lips P, Bouillon R, et al. Need for additional calcium to reduce the risk of hip fracture with vitamin D supplementation: evidence from a comparative metaanalysis of randomized controlled trials. J Clin Endocrinol Metab 2007;92:1415-23.
  17. Bischoff-Ferrari HA, Dietrich T, Orav EJ, et al. Positive association between 25-hydroxy vitamin D levels and bone mineral density: a population-based study of younger and older adults. Am J Med 2004;116:634-9.
  18. Avenell A, Gillespie WJ, Gillespie LD, et al. Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis. Cochrane Database Syst Rev 2009;3:CD000227.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2010 Bionika Media

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies