WHETHER EVIDENCES OF EFFICIENCY OF CALCIUM AND VITAMIN D IN THE PREVENTION OF OSTEOPOROTIC FRACTURES ARE STILL NECESSARY?


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Abstract

The article discusses the role of vitamin D and calcium deficiency in the pathogenesis of osteoporotic fractures. The results of randomized clinical trials, meta-analyses and systematic reviews clearly demonstrate the efficacy of a combination of vitamin D and calcium in the prevention of nonvertebral fracture, including femoral fracture. It is emphasized that the use of high-dose of vitamin D (700 - 1000 IU/day) leads to its optimal concentration in the blood serum at level of 90 - 100 nmol/L. For the purpose of improvement of treatment compliance, drug containing 1000 mg of calcium and 800 IU of vitamin D may be used once daily.

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