ADIPONECTIN AND C-REACTIVE PROTEIN AS FACTORS OF CARDIOVASCULAR RISK IN MEN WITH TYPE 2 DIABETES MELLITUS


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Abstract

The results of study devoted to assess of adiponectin, C-reactive protein (CRP) and the thickness of the intima-media complex (IMT) of carotid arteries as a risk factor for cardiovascular complications (CVC) in men with type 2 diabetes mellitus (DM2) are presented. The study enrolled 42 patients with DM2 and 10 healthy controls. Patients with diabetes mellitus were divided into groups according to the history of CVC (myocardial infarction and stroke). The findings confirmed that increased levels of CRP and increased IMT in patients with DM2 are risk factors for CVC. It was found that increased insulin resistance is an additional risk factor for stroke in men with DM2, and hypopoadiponectinemia can be considered as a risk factor for myocardial infarction. The negative correlation of blood adiponectin level with CRP and IMT of the carotid arteries confirms the anti-inflammatory action of adiponectin and its protective effects against development of atherosclerosis.

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