Peculiarities of articular syndrome treatment in elderly persons with arterial hypertension


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Abstract

The article is dedicated to the problem of adverse effects by cardiovascular system against the background of use of nonsteroidal anti-inflammatory drugs (NSAIDs) in elderly patients, particularly in patients with osteoarthritis in combination with arterial hypertension. In this case, use of non-selective NSAIDs is associated with increased risk of cardiovascular complications and leads to significant limitation of administration of antihypertensive drugs. Selective NSAID nimesulide (Nise) has no such effects, therefore it can be considered as a drug of choice for the management of acute and chronic joint syndrome in patients with arterial hypertension.

References

  1. Егоров И.В., Воробьев П.А., Цурко В.В. Поражение сердечно-сосудистой системы на ранней стадии подагры // Клиническая геронтология. 2008. № 9. С. 62.
  2. Taylor W. Management of hypertension and dyslipidaemia in patients presenting with hyperuricaemia. Clin Med 2002;80(2):77-8.
  3. Blanco FJ, Guitian R, Moreno J, et al. Effect of anti-inflammatory drugs on COX-1 and COX-2 activity in human articular chondrocytes. J Rheumatol 1999;26:1366-73.
  4. Mitchell JA, Lucas R, Vojnovic I, et al. Stronger inhibition by nonsteroid anti-inflammatory drugs of cyclooxygenase-1 in endothelial cells than platelets offers an explanation for increased risk of thrombotic events. FASEB J 2006;20:2468-75.
  5. Langman MJ, Weil J, Wainwright P, et al. Risks of bleeding peptic ulcer associated with individual non-steroidal anti-inflammatory drugs. Lancet 1994;343:1302.
  6. Pritchard G, Lyons D, Webster J. Do trandolapril and indomethacin influence renal function and renal functional reserve in hypertensive patients? Br J Clin Pharmacology 1997;44(2):145-9.
  7. Breyer MD, Breyer RM. Prostaglandin E receptors and the kidney. Am J Physiology 2000;279(1):12-23.
  8. Quilley J, Bell-Quilley CP, McGiff JC. Eicosanoids and hypertension. Hypertension / Ed. J.H. Laragh, B.M. Brenner. - N. Y.: Raven Press, 1995;1:963-82.
  9. Smit-van Oosten A, Boonstra AH, Navis G, et al. Reduced cyclooxygenase involvement in renal vascular endothelial function. Nephron Physiol 2005;100:21-30.
  10. Fries S, Grosser T. The Cardiovascular Pharmacology of COX-2 Inhibition. Hematology Am Soc Hematol Educ Program 2005:445-51.
  11. Егоров И.В., Цурко В.В. Суставной синдром в ревматологии: современная патогенетическая концепция и обоснование терапевтического применения немисулида // Фарматека. 2008. № 8. С. 37-41.
  12. Rainsford K.D. Nimesulide - a multifactorial approach to inflammation and pain: scientific and clinical consensus. Curr Med Res Opin 2006;22:1161-70.
  13. Барскова В.Г., Якунина И.А., Насонова В.А.. Применение нимесила при подагрическом артрите // Терапевтический архив. 2003. Т. 5. С. 60-4.
  14. Gatcia Rodrigues LI, Patrignani P. The ever growing story of cyclooxygenase inhibition. Lancet 2006;368:1745-7.
  15. Nilsson SE, Takkinen S, Tryding N, et al. Arterial hypertension and purine metabolic disorder. Best Pract Res Clin Rheumatol 2004;18:111-24.
  16. Sandler DP, Burr FR, Weinberg CR. Non-steroidal anti-inflammatory drugs and the risk for chronic renal disease. Ann Intern Med 1991;115:165-72.
  17. Avanzini F, Palumbo G, Alli C, et al. Effects of low dose aspirin on clinic and ambulatory blood pressure in treated hypertensive patients. Am J Hypertens 2000;13:611-6.
  18. Johnson AC, Nguyen TV, Day RO. Do Nonsteroidal Anti-inflammatory Drugs Affect Blood Pressure? A Meta-Analysis. Ann Intern Med 1994;121:289-300.
  19. Dahlof B, Sever P, Poulter NR. ASCOT Investigators. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomized controlled trial. Lancet 2005;366:895-906.
  20. Чазова И.Е., Ратова Л.Г. Антагонисты кальция в лечении артериальной гипертонии (исследование ЭТНА) // Consilium medicum. 2005. Т. 7. С. 25-27.
  21. Khan S. Nimesulide and adverse drug reactions: Time for a database. J Postgrad Med 2008;54:242-46.
  22. Мареев В.Ю., Агеев Ф.Т., Арутюнов Г.П. и др. Применение диклофенака и целебрекса у пациентов с артериальной гипертонией, остеоартрозом и болями в нижней части спины на фоне гипотензивной терапии аккупро или норваском (исследование ДОЦЕНТ) // Сердечная недостаточность. 2005. № 5. С. 204-208.
  23. Aw TJ, Haas SJ, Liew D, et al. Meta-analysis of cyclooxygenase-2 inhibitors and their effects on blood pressure. Arch Intern Med 2005;165:490-96.

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