DEGENERATIVE DISC DISEASE AS MANIFESTATION OF CONNECTIVE TISSUE DYSPLASIA: TRACE ANALYSIS OF HERNIATIONS OF INTERVERTEBRAL DISK AND EVALUATION OF THERAPEUTIC EFFECTS OF DRUG MAGNEROT

Degenerative disc disease is one of the most important problems of clinical medicine. Our previous systematic analysis of the molecular mechanisms showed the paramount significance of magnesium in maintenance of structure and function of connective tissue. The present work is the first experimental and clinical study of trace-element composition of herniation of intervertebral disc and influence of therapy with magnesium orotate on the course of the disease. The study, which included 60 patients with manifest degenerative spine pathology, showed that they all have obvious signs of connective tissue dysplasia on a background of magnesium deficiency, which greatly aggravates clinical symptoms of degenerative spine pathology and leads to exasperation and chronification of pain syndrome. Significant decrease in clinical manifestations of magnesium deficiency was observed in patients treated with magnesium orotate; patients reported improved sleep, stabilized blood pressure, regression of chest discomfort, arrhythmias, and convulsions in the legs. Fundamental difference in the histology of the connective tissue of hernias was established: Type 1 -loose, fragile and friable tissue, Type 2 - dense, viscous, and rubbery tissue. The Type 1 hernias are accompanied by lower content of magnesium, boron, zinc and lithium in the hair. As shown in the present study, the correlation of clinical and histological manifestations of the disease with the microelement status of the patient can be used to predict the patient's condition and order individual entry, including magnesium preparations.

degenerative disk diseases, herniation of intervertebral disc, connective tissue dysplasia, magnesium deficiency, magnesium orotate, Magnerot