RESORBA IN THE TREATMENT OF BONE METASTASIS OF BREAST CANCER


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Abstract

The article discusses the problem of the treatment of metastatic bone disease. In clinical practice, application of bisphosphonates, which action is directed to a specific correction of mineral metabolism and selective effect on bone metastases, has opened up new opportunities for palliative care of cancer patients. The results of study of 24 patients with metastatic breast cancer (BC) aimed to evaluation of efficacy of zoledronic acid (Resorba) are presented. The results showed efficacy and good tolerability of domestic preparation Resorba in breast cancer patients with multiple bone metastases.

References

  1. Boissier S, Ferrers M, Peyruchaud O, et al. Bisphosphonates inhibit breast and prostate carcinoma cell invasion an early event in the formation of bone metastase. Cancer Res 2000;60:2949-54.
  2. Braun JE, Thomson C, Ellis S, et al. Bone resorption predicts for skeletal complications in metastatic bone disease. Br J Cancer 2003;89:2031-7.
  3. Coleman RE. Clinical features of metastatic bone disease and risk of skeletal morbidity. Clin Cancer Res 2006;12(20):6243-9.
  4. Coleman RE. Potential use of bisphosphonates in the prevention of metastasis in early-stage breast cancer. Clin Breast Cancer 2007;7(1):29-35.
  5. Harvey MA, L. von Reyn Cream. Biology of bone Metastases: Causes and Consequences. J Clin Breast Cancer 2007;7(l):7-13.
  6. Roodman DG. Mechanism of bone metastases. N Eng J Medicine 2004;350:1655-64.
  7. Rosen LS, Gordon D, Tchekmodyian S, et al. Zoledronic acid versus placebo in the treatment of skeletal metastases in patients with lung cancer and other solid tumors: a phase III, double-blind, randomized trial. J Clin Oncol 2003;21:3150-7.
  8. Rosen LS, Gordon DH, Dugan et al. Zolendronic acid is superior to pamidronate for the treatment of bone metastases in breast carcinoma patients with at least one osteolytic lesion. Cancer 2004;100:36-43.
  9. Senartne SG, Pirianov G, Mansi JL, et al. Bisphosphonates induce apoptosis in human breast cancer cell lines. Br J Cancer 2000;82:1459-68.
  10. Алиев М.Д., Болотина Л.В., Тепляков В.В. и др. Применение зометы в лечении метастатического поражения скелета // Современная онкология 2004. № 3. С. 113-6.
  11. Кондратьева А.П., Поддубная И.В. Роль биисфосфонатов в лечении рака молочной железы. Кафедра онкологии РМАПО, Москва. // Современная онкология. 2004. Т. 6. № 2. С. 63-4.
  12. Матвеев Б.П., Карякин О.Б., Матвеев В.Б. и др. Зомета в лечении больных распространенным раком предстательной железы // Современная онкология 2004. № 3. С. 111-3.

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