RENAL CELL CARCINOMA. PAST, PRESENT AND FUTURE


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Abstract

We discuss the problem of renal cell carcinoma (RCC), which has the third place in rate of increase of cancer morbidity in Russia. Statistics of the incidence, risk factors, classification of RCC, the clinical picture of kidney cancer, methods of diagnosis and treatment are presented. Currently, along with the surgical and immunological methods for the treatment of metastatic RCC, new drugs - angiogenesis inhibitors are administrated in practice. The major pathogenetic mechanism of these drugs is prevention the neoangiogenesis of the tumor. One of the drugs in this group is sunitinib - tableted tyrosine kinase inhibitor, which affects all known types of receptors for growth factors involved in the process of tumor growth, pathologic angiogenesis and metastasis. Results of multicenter randomized clinical trials for assessment of sunitinib as the first- and second-line treatment of patients with metastatic RCC showed its high efficacy and low frequency of reported side effects.

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