AUTOIMMUNE PANCREATITIS IN PEDIATRIC PRACTICE


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Autoimmune pancreatitis (AP) is one of number of little-known diseases and has not been described in children. The article presents modern data for epidemiology, pathogenesis, morphological and clinical features of AP, and international criteria for its diagnosis. Among 57 children with proven chronic pancreatitis, which were observed by authors, AP was diagnosed in 4 cases; moreover, in 2 cases it was secondary on the background of inflammatory bowel disease, while in 2 children - primary. Primary AP was characterized by symptomatic course; immunological AP markers were identified: high level of IgG4, antibodies to lactoferrin. Treatment with prednisolone resulted in rapid reduction of the exacerbation; the long-term remission was possible against the background of treatment with thiopurines and enzymotherapy with Creon.

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