MODERN ANTIHISTAMINES: CHOICE IN ABUNDANCE OF DRUGS


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Abstract

The article presents the review of current data for pharmacodynamics, pharmacokinetics, clinical efficacy and side effects of new 2-nd generation antihistamines. Desloratadine (Lordestin) has the highest selectivity and affinity for the H1-receptor, has a properties of antagonist and inverse agonist, does not cross the blood-brain barrier and has minimal sedative effect. 2-nd generation drugs have antiinflammatory action that is not associated with H1-blockade and is based on suppression of the release of inflammatory mediators and suppression of cellular response (adhesion, chemotaxis, etc.). Desloratadine has favorable pharmacokinetics and the largest half-life; despite the presence of metabolism, drug interactions are absent. Clinical trials and postmarketing studies have shown high efficacy of desloratadine in relief of symptoms of allergic rhinitis and recurrent urticaria and in improvement of quality of life; drug was well tolerated.

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