COMPLEX THERAPY OF DIABETIC FOOT SYNDROME IN PATIENTS WITH TYPE 2 DIABETES MELLITUS WITH PURULO-NECROTIC LESSIONS OF LOWER LIMBS

Texto integral

Resumo

The article presents the results of assessment of the effectiveness of the drug Actovegin as a part of complex therapy in patients with diabetic foot syndrome (DFS) subjected to surgical treatment. The effect of Actovegin on microvascular blood flow in these patients in the postoperative period was examined. Experimental group included 138 patients, all of them received intravenous Actovegin; control group included 92 patients who received standard therapy. It was shown that surgical treatment of patients with purulo-necrotic lesions of lower limbs against the background of type 2 diabetes mellitus in combination with the use of Actovegin allow to stabilize the wound process and normalize the time of all its phases. According to the results of evaluation of transcutaneous oxygen tension, use of the drug Actovegin in complex treatment of patients with various forms of DFS leads to significant improvement of microcirculation.

Bibliografia

  1. Балаболкин М.И. Сахарный диабет. М., 1994. С. 382.
  2. Дедов И.И. Осложнения сахарного диабета (клиника, диагностика, лечение, профилактика). М., 1995. С. 24.
  3. Дедов И.И., Анциферов М.Б., Галстян Г.Р., Токмакова А.К. Синдром диабетической стопы. Клиника, диагностика, лечение и профилактика. М., 1998. С. 143.
  4. Доклад комитета экспертов ВОЗ: Сахарный диабет. Серия техн. Доклад № 646. М., 1987. С. 68.
  5. Князев Л.П., Киржатов С.И., Дзагоев Г.П. Комплексное лечение диабетической апгиопатии нижних конечностей. Труды IX симпозиума по хирургической эндокринологии. Ульяновск, 1996. С. 53-55.
  6. Толстых П.И., Кривихин В.Т., Луцевич Э.В. Лазерное излучение и антиоксиданты в лечении гнойно-некротических процессов нижних конечностей у больных сахарным диабетом. М., 1998. С. 120.
  7. Dyck PJ, Karnes JL, O'Brein PC. The Rochester Diabetic neuropathy study: Reassessment of test and criteria for diagnosis and staged seventy. Neurology 1990;42:1164-70.
  8. Gill GV. Insulin dependent diabetes mellitus. In: Textbook of diabetes, eds. Pickup G., Williams G., Oxford, Blackwell Scientific Publications. 1991.
  9. Kamal K, Powell R, Sumpio B. The pathobiology of diabetes mellitus: Implications for surgeons. J Am Coll Surg 1996;183:281-89.
  10. Knox RC, Dutch W, Blume P. Diabetic Foot Disease. Int J Angiology 2000;9:1-6.
  11. MeWhInie DL, Gordon AC, et al. RehablUtation outcome 5 years after 100 lower limb amputatis)ns. Br J Surg 1994;81:1596-99.
  12. Reiber G, Boulton AA, Tleikyte E, et al. Causal pathways to lower extremity foot ulcers. Diabetes care 1999;22:157-62.
  13. Reiber GE, Boyko EJ, Smith DG. Lower extremity foot ulcers and amputations in diabetes. In: Harris MI. Cowie C. Stern MP. Diabetes in America 1995:95-1468.
  14. The Diabetes Control and Complications Trial Research Group. 1999.

Arquivos suplementares

Arquivos suplementares
Ação
1. JATS XML

Declaração de direitos autorais © Bionika Media, 2011