ADHERENCE TO THERAPY WITH COFORMULATED DRUG CONSISTING OF CALCIUM AND VITAMIN D IN DIFFERENT DOSAGE


Cite item

Full Text

Abstract

The study including 70 patients aged 45-65 years with postmenopause for at least 2 years and osteopenia at the lumbar spine and/or femoral neck according to WHO criteria (T-test, -1,0 SD to -2,49 SD) was aimed to evaluation of adherence to treatment, the womens preferences to the various schemes of osteoporosis prevention with drug containing calcium and vitamin D. Group 1 received calcium at a dose 1000 mg and vitamin D3 at a dose 800 IU once a day in the evening, Group 2 - 500 mg calcium and 400 IU of vitamin D3 twice a day (Calcium-D3 Nycomed Forte). Regardless of the treatment regimen, very high adherence to therapy (96%) was observed. In 40% of patients, receiving of drug once a day was more convenient, 33% of patients preferred administration of drug twice a day, and 27% reported that treatment regimen was no great shakes.

References

  1. Остеопороз. Диагностика, профилактика и лечение. Клинические рекомендации / Под ред. О.М. Лесняк, Л.И. Беневоленской. М., 2010, C. 272.
  2. Древаль А.В., Марченкова Л.А., Добрицына М.А. Уровень потребления кальция с продуктами питания у здорового населения Московской области // Остеопороз и остеопатии 2010. № 1. С. 54.
  3. Торопцова Н.В., Никитинская О.А., Беневоленская Л.И. Профилактика первичного остеопороза с помощью различных препаратов кальция // Научно-практическая ревматология 2005. № 1. C. 36-39.
  4. Рожинская Л.Я. Кальций и витамин D в профилактике и лечении остеопороза. В кн. Руководство по остеопорозу / Под ред. Л.И. Беневоленской. М., 2003. С. 261-88.
  5. Heaney RP. Bone health. Am J Clin Nutr 2007;85(1):300-303.
  6. Erdine S. Compliance with the treatment of hypertension: the potential of combination therapy. J Clin Hypertens (Greenwich) 2010;12(1):40-46.
  7. World Health Organization. Adherence to long-term therapies: evidence for action. Geneva: WHO, 2003.
  8. Sanfelix-Genoves J, Gil-Guillen V.F., Orozco-Beltran D, et al. Determinant factors of osteoporosis patients' reported therapeutic adherence to calcium and/or vitamin D supplements: a cross-sectional, observational study of postmenopausal women. Drugs Aging 2009;26(10):861-69.
  9. Berry SD, Misra D, Hannan MT, et al. Low Acceptance of Treatment in the Elderly for the Secondary Prevention of Osteoporotic Fracture in the Acute Rehabilitation Setting. Aging Clin Exp Res 2010;22(3):231-37.
  10. Сафонова Ю.А., Зоткин Е.Г. Приверженность лечению пациентов с остеопорозом в реальной клинической практике // Остеопороз и остеопатии 2010. № 1. С. 114.
  11. Spangler M, Phillips BB, Ross MB, et al. Calcium supplementation in postmenopausal women to reduce the risk of osteoporotic fractures. Am J Health Syst Pharm 2011;68(4):309-18.
  12. Tang B.M., Eslick G.D., Nowson C. et al. Supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis. Lancet, 2007; 370:656-66.
  13. Simonelli C, Chen Y, Morancey J, et al. Evaluation and management of osteoporosis following hospitalization for low-impact fracture. J Gen Intern Med 2003;18(1):17-22.
  14. Kuo I, Ong C, Simmons L, et al. Successful direct intervention for osteoporosis in patients with minimal trauma fractures. Osteoporosis Int 2007;18(12):1633-39.
  15. Hill DA, Cacciatore M, Lamvu GM. Electronic prescribing influence on calcium supplementation: a randomized controlled trial. Am J Obstet Gynecol 2010;202(3):236.e1-5.
  16. den Uyl D, Geusens PP, van Berkum FN, et al Patient preference and acceptability of calcium plus vitamin D3 supplementation: a randomised, open, cross-over trial. Clin Rheumatol 2010;29(5):465-72.
  17. Зоткин Е.Г., Сафонова Ю.А. Нужны ли еще доказательства эффективности кальция и витамина D в профилактике остеопоротических переломов? // Фарматека 2010. № 8 (202). С. 38-42.
  18. McGill JB. Optimal use of beta-blockers in high-risk hypertension: a guide to dosing equivalence. Vasc Health Risk Manag 2010;1(6):363-72.
  19. Kane S. Does treatment schedule matter? Once daily versus divided doses of 5-ASAs. Dig Dis 2010;28(3):478-82.
  20. Price D, Robertson A, Bullen K, et al. Improved adherence with once-daily versus twice-daily dosing of mometasone furoate administered via a dry powder inhaler: a randomized open-label study. BMC Pulm Med 2010;10:1.
  21. Ivanovich P, Fellows H, Rich C. The absorption of calcium carbonate. Ann Int Medicine 1967;66(5):917-23.
  22. Heaney RP, Smith KT, Recker RR, et al. Meal effects on calcium absorption. Am J Clin Nutr 1989;49:372-76.
  23. Micheletti MC, Zartarian M. Comparison of calcium retention measured using a radionuclide method after administration of 1 000 mg elemental calcium in two different galenic forms, in one or two doses. Rev Rhum (English Ed) 1996;63:51-55.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2011 Bionika Media

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies