PLACE OF ASPIRIN IN THE THERAPY OF ATHEROTHROMBOSIS AND ITS COMPLICATIONS


Cite item

Full Text

Abstract

The article is dedicated to the mechanisms of the atherothrombotic process, and the morphological properties of atherosclerotic plaques. Taking into account the leading role of platelet component of hemostasis in thrombogenesis, drugs affecting platelet function, especially acetylsalicylic acid (ASA), serve as a primary means of treatment of atherothrombosis and its complications. The results of clinical trials of ASA are presented; it is emphasized that today the ASA remains the most available and widely used antithrombotic drug for both secondary and primary prevention of cardiovascular diseases.

References

  1. Панченко Е.П. Атеротромбоз: механизмы развития и реально проводимая терапия // Атеротромбоз 2008. № 1. С. 22-6.
  2. Patrono C, Bachmann F, Baigent C, at al. Expert Consensus Document on the Use of Antiplatelet Agents. Eur Heart J 2004;25:166-81.
  3. Antithrombotic Trialists' Collaboration Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ 2002;324:71-86.
  4. Лагута П.С., Панченко Е.П. Актуальные вопросы терапии аспирином // Сердце 2005. № 4. С. 17-23.
  5. Гиляров М.Ю. Ацетилсалициловая кислота: нестареющий ветеран // Клиницист 2006. № 4. С. 60-8.
  6. Hamm C, Bassand J, Agewall S, at al. ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevationю Eur Heart J 2011. Sep 21. [Epub ahead of print]
  7. The ISIS-2 Collaborative Group Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. Lancet 1988;2:349-60.
  8. Van de Werf F, Bax J, Betriu A, at al. ESC Guidelines for the management of acute myocardial infarction in patients presenting with persistent ST-segment elevation. Eur Heart J 2008;29:2909-45.
  9. Wijns W, Olh P, Аnchin N, at al. ESC Guidelines on myocardial revascularization. Eur Heart J 2010;31:2501-55.
  10. Chen ZM. CAST: randomised placebo-controlled trial of early aspirin use in 20000 patients with acute ischaemic stroke. Lancet 1997;349:1641-49.
  11. The International Stroke Trial Collaborative Group The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischaemic stroke. Lancet 1997;349:1569-81.
  12. Sandercock PA, Counsell C, Gubitz GJ at al. Antiplatelet therapy for acute ischaemic stroke Cochrane Database Syst Rev 2008;16:CD000029.
  13. Adams H, del Zoppo G, Alberts M, at al. AHA/ASA Guidelines for the Early Management of Adults With Ischemic Stroke. Stroke 2007;38:1655-1711.
  14. Tendera M, Aboyans V, Bartelink ML, at al. ESC Guidelines on the diagnosis and treatment of peripheral artery diseases. Eur Heart J 2011. Aug 26. [Epub ahead of print]
  15. Гиляров М.Ю. Место ацетилсалициловой кислоты в современной фармакотерапии сердечно-сосудистых заболеваний // Кардиология 2007. № 9. С. 90-6.
  16. CAPRIE Steering Committee A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet 1996;348:1329-39.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2011 Bionika Media

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies