POTENTIALS FOR USE OF ANGIOTENSIN-CONVERTING ENZYME INHIBITOR PRESTARIUM A IN CORRECTION OF CORONARY AND MYOCARDIAL RESERVES IN PATIENT WITH CORONARY HEART DISEASE: CLINICAL DISCUSSION


Cite item

Full Text

Abstract

The article presents the results of examination and treatment of a patient aged 54 years with coronary heart disease (effort angina, postinfarction cardiosclerosis) and arterial hypertension. Inclusion of tissue-specific ACE inhibitor perindopril (Prestarium A) in the complex therapy had a restorative effect on endothelial dysfunction, as well as additional antianginal and anti-ischemic effects in terms of reducing the severity of anginal syndrome, increased exercise tolerance, etc.

References

  1. The REACH registry Investigators. JAMA 2006;295:180-89. Cangiano E, Marchesini J, Campo G, et al. ACE inhibition modulates endothelial apoptosis and renewal via endothelial progenitor cells in patients with acute coronary syndromes. Am J Cardiovasc Drugs 2011;11:189-98.
  2. Linz W, Wiemer G, Gohlke P, et al. Contribution of kinins to the cardiovascular actions of angiotensin-converting enzyme inhibitors. Pharmacol Rev 1995;47:25-49.
  3. Pieruzzi F, Abassi ZA, Keiser HR. Expression of renin-angiotensin system components in the heart, kidneys, and lungs of rats with experimental heart failure. Circulation 1995;92:3105-12.
  4. Ceconi C, Fox KM, Remme WJ, et al. ACE inhibition with perindopril and endothelial dysfunction: results of a substudy of the EUROPA study-PERTINENT. Cardiovasc Res 2007;73:237-246.
  5. Ferrari R. Angiotensin-converting enzyme inhibition in cardiovascular disease: evidence with perindopril. Expert Rev Cardiovasc Ther 2005;3:15-29.
  6. Rodriguez-Granillo GA. Long-term effect of Perindopril on coronary atherosclerosis progression (from the PERindopril's Prospective Effect on Coronary aTherosclerosis by Angiography and IntraVascular Ultrasound Evaluation [PERSPECTIVE] Study). Am J Cardiol 2007;100:159-63.
  7. The Treatment Effect of Perindopril is Consistent in All Patients with Vascular Disease or High Risk of Vascular Disease: A Combined Analysis of Three Perindopril Trials. Circulation 2008;118:S1138.
  8. Baker WL, Coleman CI, Kluger J, et al. Systematic review: comparative effectiveness of angiotensin-converting enzyme inhibitors or angiotensin II-receptor blockers for ischemic heart disease. Ann Intern Med 2009;151:861-71.
  9. Морозова Т.Е., Вартанова О.А., Михайлова Н.В. Возможности коррекции коронарного и миокардиального резервов у больных ишемической болезнью сердца ингибитором ангиотензин-превращающего фермента периндоприлом // Кардиология. 2008. № 8. С. 9-15.
  10. Морозова Т.Е., Вартанова О.А., Михайлова Н.В. Дисфункция эндотелия при ишемической болезни сердца и возможности ее фармакологической коррекции // Клиническая фармакология и терапия. 2009. Т. 18. № 3. С. 45-49.

Supplementary files

Supplementary Files
Action
1. JATS XML

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies