CAPECITABINE AND FLUOROURACIL IN THE TREATMENT OF COLORECTAL CANCER AND GASTRIC CANCER: ANALYSIS OF DIRECT COMPARATIVE STUDIES


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Abstract

The review considers the place of capecitabine as an alternative to fluorouracil (5-FU) in the treatment of colorectal cancer (CRC) and gastric cancer (GC). Based on the results of randomized clinical trials, it was concluded that treatment regimens with capecitabine have equal efficacy compared with those based on infusional 5-FU in terms of overall survival in patients with colorectal cancer. At the same time, capecitabine is likely to be even more effective alternative to 5-FU in metastatic GC.

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