MYELODYSPLASTIC SYNDROME AND CHELATION THERAPY


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Abstract

The article considers the clinical picture of myelodysplastic syndrome (MDS), which varies from long-term stabile course to the cases of transformation in acute myeloid leukemia for several months. Anemia - the most frequent type of cytopenia in MDS patients. For most patients, transfusion therapy remains the single method for correction, which, however, can cause myocardial damage. Chelation therapy in patients with MDS is used for correction of complications caused by post-transfusion iron excess. The general principles of chelation therapy, and drugs used for such treatment (primarily, deferasirox) are discussed. The clinical observation of the MDS patient receiving deferasirox (EXJADE) for the treatment of complications of transfusion therapy is presented.

References

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