ISSLEDOVANIE GORMONAL'NOGO FONA U MUZhChIN S PERELOMAMI PROKSIMAL'NOGO OTDELA BEDRA


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Osteoporotic fractures occur in 27 % of men aged 50 years and older, their risk further increases, but the problem of osteoporosis in men has been insufficiently studied. Purpose of study: evaluation of endocrine profiles in 128 men with proximal femoral fractures (PFF) aged 40-69 years in the cross-sectional study. Assessment of hormone levels was performed by electrochemiluminescence ECLIA., Elecsys 2010 (Roche). Statistical analysis was performed using Statistica 10.0 software. A significant decrease in testosterone levels and high levels of 17-estradiol and prolactin, as well as the high frequency of 25(OH)-vitamin D deficiency compared with controls, were observed in patients with PFF in study groups. Thus, PFF in men occur against the background of reducing the concentration of testosterone and the presence of 25 (OH)-vitamin D deficiency.

Full Text

Restricted Access

References

  1. Khosla S., Amin S., Orwoll E. Osteoporosis in men. Endocr Rev 2008; 29(4): 441-64.
  2. Khosla S. Update in male osteoporosis. J Clin Endocrinol Metab 2010; 95(1): 3-10.
  3. Forsen L., Sogaard A.J., Meyer H.E., et al. Survival after hip fracture: short- and long-term excess mortality according to age and gender. Osteoporos Int 1999; 10: 73-8.
  4. Kanis J.A., Oden A., McCloskey E.V., et al. A systematic review of hip fracture incidence and probability of fracture worldwide. Osteoporos Int 2012; 21 (2).
  5. Михайлов Е.Е., Беневоленская Л.И., Аникин С.Г. и др. Частота переломов проксимального отдела бедренной кости и дистального отдела предплечья среди городского населения России // Остеопороз и остеопатии 1999. № 3. С. 2-6.
  6. Ершова О.Б., Белова К.Ю., Ганерт О.А. и др. Организация помощи больным с переломами проксимального отдела бедра на фоне остеопороза // РМЖ. Ревматология 2010. № 27. 1672 с.
  7. Riggs B.L., Khosla S., Melton L.J. Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev 2002; 23: 279-302.
  8. Clarke B.L., Khosla S. Pathophysiology of Age-Related Bone Loss in Men. Radiol Clin North Am 2010; 48(3): 483-95.
  9. Falahati-Nini A., Riggs B.L., Atkinson E.J., et al. Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men. J Clin Invest 2000; 106(12): 1553-60.
  10. Bjornerem A., et al. A prospective study of sex steroids, sex hormone-binding globulin, and nonvertebral fractures in women and men: the Tromso Study Eur J Endocrinol 2007; 157: 119-25.
  11. Amin S., et al. Estradiol, testosterone, and the risk for hip fractures in elderly men from the Framingham Study Am J Med 2006; 119: 426-33.
  12. Meier C., et al. Endogenous sex hormones and incident fracture risk in older men: the Dubbo Osteoporosis Epidemiology Study. Arch Intern Med 2008; 168: 47-54.
  13. Eriksen E.F., Mosekilde L., Melsen F. Trabecular bone remodeling and bone balance in hyperthyroidism. Bone 1985; 6: 421-28.
  14. Lee M.S., Kim S.Y., Lee M.C., et al. Negative correlation between the change in bone mineral density and serum osteocalcin in patients with hyperthyroidism. J Clin Endocrinol Metab 1990; 70: 766-70.
  15. Orwoll E.S., Bevan L., Phipps K.R. Determinants of bone mineral density in older men. Osteoporos Int 2000; 11: 815-21.
  16. Deutschmann H.A., Weger M., Weger W., et al. Search for occult secondary osteoporosis: impact of identified possible risk factors on bone mineral density. J Intern Med 2002; 252: 389-97.
  17. Cauley J.A., Fullman R.L., Stone K.L., et al. Factors associated with the lumbar spine and proximal femur bone mineral density in older men. Osteoporos Int 2005; 16: 1525-37.
  18. Lau E.M., Suriwongpaisal P., Lee J.K., et al. Risk factors for hip fracture in Asian men and women: the Asian osteoporosis study. J Bone Miner Res 2001; 16: 572-80.
  19. Heijckmann A.C., Huijberts M.S., Geusens P., et al. Hip bone mineral density, bone turnover and risk of fracture in patients on long-term suppressive L-thyroxine therapy for differentiated thyroid carcinoma. Eur J Endocrinol 2005; 153: 23-9.
  20. Greenspan S.L., Neer R.M., Ridgway E.C., Klibanski A. Osteoporosis in men with hyperprolactinemic hypogonadism. Ann Intern Med 1986; 104(6): 777-82.
  21. DiSomma C., Colao A., DiSarno A., et al. Bone marker and bone density responses to dopamine agonist therapy in hyperprolactinemic males. J Clin Endocrinol Metab 1998; 83(3): 807-13.
  22. Riggs B.L., Khosla S., Melton L.J. A unitary model for involutional osteoporosis: estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men. J Bone Miner Res 1998; 13(5): 763-73.
  23. Kennel K.A., Riggs B.L., Achenbach S.J., et al. Role of parathyroid hormone in mediating age-related changes in bone resorption in men. Osteoporos Int 2003; 14(8): 631 -36.
  24. Krall E.A., Sahyoun N., Tannenbaum S., et al. Effect of vitamin D intake on seasonal variations in parathyroid secretion in postmenopausal women. N Engl J Med 1989; 321: 1777-83.
  25. Lips P., Hackeng W.H.L., Jongen M.J.M., et al. Seasonal variation in serum concentrations of parathyroid hormone in elderly people. J Clin Endocrinol Metab 1983; 57: 204-06.
  26. Brown J.P., Josse R.G. 2002 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada. CMAJ 2002; 167(10): 34.
  27. Ensrud K.E., Taylor B.C., Paudel M.L., et al.; Osteoporotic Fractures in Men Study Group. Serum 25-Hydroxyvitamin D levels and rate of hip bone loss in older men. J Clin Endocrinol Metab 2009; 94(8): 2773-80.
  28. Rosen C.J., Gallagher J.C. The 2011 IOM report on vitamin D and calcium requirements for north america: clinical implications for providers treating patients with low bone mineral density. J Clin Densitom 2011; 14(2): 79-84.
  29. Никитинская О.А., Торопцова Н.В., Беневоленская Л.И. Роль кальция и витамина Д в профилактике остеопороза и связанных с ним переломов // Журнал "Медицинский совет" 2007. № 2.
  30. Rekeneire N., et al. Is a fall just a fall: correlates of falling in healthy older persons. The Health, aging and body composition study. J. Am Geriatr Soc 2003; 51: 841-46.
  31. Nevitt M.C., et al. Risk factors for recurrent non- syncopal falls. A prospective study. JAMA 1989; 261: 2663-68.
  32. Nordin B.E.C., Need A.G., Morris, H.A., Horowitz M. The special role of "hormonal" forms of vitamin D in the treatment of osteoporosis. Calcif Tissue Int 1999; 65: 307-10.
  33. Lau K.H.W., Baylink D.J. Vitamin D therapy of osteoporosis: plain vitamin D therapy versus active vitamin D analog (D-hormone) therapy. Calcif Tissue Int 1999; 65: 295-306.
  34. Boland R. Role of vitamin D in skeletal muscle function. Endocr Rev 1986; 784: 434-48.
  35. Bischoff H.A., Borchers M., Gudat F., et al. In situ detection of 1,25-dihydroxyvitamin D receptor in human skeletal muscle tissue. Histochem 2001; 33: 19-24.
  36. Bischoff H.A., Stahelin H.B., Urscheler N., et al. Muscle strength in the elderly: its relation to vitamin D metabolites. Arch Phys Med Rehabil 1999; 80: 54-8.
  37. Dukas L., Schacht E., Bischoff H.A. Better functional mobility in community dwelling elderly is related to Dhormone serum levels and to a daily calcium intake. Accepted for publication in Journal on Nutrition, Health and Aging, 2005.
  38. Papadimitropoulos, et al. Meta-analisis of the Efficacy of Vitamin D Treatment in Preventing Osteoporosis in Postmenopausal Woman. Endoc Rev 2002; 23(4): 560-69.
  39. Richy F., Ethgen O., Bruyere O., et al. Efficacy of alphacalcidol and calcitriol in primary and corticosteroid-induced osteoporosis: a meta-analysis of their effects on bone mineral density and fracture rate. Osteoporos Int 2004; 15(4): 301 -10.
  40. Richy F., et al. Vitamin D Analogs Versus Native Vitamin D in Preventing Bone Loss and Osteoporosis-Related Fractures: A Comparative Meta-analysis. Calcif Tissue Int 2005; 76: 176-86.
  41. Richy F., et al. Differential effects of D-gormon analogs and native vitamin D on the risk of falls: a comparative meta-analysis. Calcif Tissue Int 2008; 82(2): 102-07.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2012 Bionika Media

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies