SUSTAINED-RELEASE METFORMIN (GLUCOPHAGE LONG) IN THE MANAGEMENT OF TYPE 2 DIABETES MELLITUS
- Authors: Nikonova T.V.1, Nikonova TV1
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Affiliations:
- Issue: No 3 (2012)
- Pages: 49-52
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/279288
- ID: 279288
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Full Text
Abstract
Metformin is first-line drug in the treatment of type 2 diabetes mellitus. Original metformin Glucophage is successfully applied in practice for over 50 years. However, adverse effects on the gastrointestinal tract are common in patients receiving metformin; furthermore, they cause discomfort and in some cases require withdrawal of drug. An innovative form of sustained-release metformin (Glucophage Long®), which is based on a dual polymer matrix (system of diffusion through the gel barrier), allows the effective control of glycemia within 24 hours while taking the drug once a day and provides better tolerability compared with the conventional metformin. This new dosage form can improve patients' adherence to metformin.
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