EFFICACY AND SAFETY OF A FIXED COMBINATION OF IBUPROFEN/PARACETAMOL IN FEBRILE AND PAIN SYNDROME IN AMBULATORY PRACTICE


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Abstract

The article presents the results of qualitative and quantitative analysis of the efficacy and safety of fixed combination of ibuprofen/paracetamol in the relief of fever syndrome (FS) and pain syndromes (PS) of various origins in the outpatient settings compared with monotherapy of these pathological states with ibuprofen and paracetamol. The study included 260 patients randomized to three parallel groups, each of which received one of the drugs. Groups were formed separately for patients with FS (n=130) and PS (n=130). It was found that combination of drugs ibuprofen/paracetamol has a marked antipyretic action after the first dose in patients with FS which is mounting after the second and third doses for the first day of observation, and from the second day of treatment was significantly higher than the similar effects of monotherapy. In patients with PS, a combination of ibuprofen/paracetamol after the first dose shows a pronounced analgesic effect that persists somewhat longer than that of monotherapy, and progressive increases after the second and third doses over the first day, and becomes stable, irreversible, and significantly higher than that of corresponding monotherapies on the third day of treatment. It is the author's opinion that this combination can be considered as a first-line symptomatic and pathogenetic therapy of FS and PS of various origins in the outpatient settings.

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