HEADACHE ASSOCIATED WITH ABUNDANT USE OF DRUGS (REBOUND HEADACHE)


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Headache associated with abundant use of drugs (drug-induced headache, rebound headache) is chronic headache occurring within 15 days a month or more, which develops as a result of abundant use of any analgetics, and regresses after withdrawal of drugs. Prevalence of drug-induced headache in the population is 1-2%. Deficit of serotonergic systems and central sensitization play a key role in the development of drug-induced headache. Rational pharmacotherapy of headache attack, prophylaxis and treatment of withdrawal symptoms are effective in more than 70% of patients with drug-induced headache.

Bibliografia

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