RANDOMIZIROVANNOE ISSLEDOVANIE EFFEKTIVNOSTI MAGNIYa OROTATA V KOMPLEKSNOY PROGRAMME REABILITATsII PATsIENTOV, PERENESShIKh OPERATsIYu PO UDALENIYu GRYZhI MEZhPOZVONOChNOGO DISKA

Degenerative diseases of the spine are one of the most pressing problems of clinical medicine. Our own previous systematic reviews of the molecular mechanisms revealed the importance of magnesium in a number of physiological processes - regulation of excitability of neurons, vasodilation, maintenance of the structure and function of connective tissue. Magnesium deficiency significantly aggravates the clinical manifestations of degenerative spine disease, leading to the increased and chronic pain. The effects of therapy with magnesium orotate (MO) in the course of rehabilitation of 60 patients after operation for excision of hernia of intervertebral disk were evaluated. Patients were randomized into two groups: 30 patients were treated with MO in combination with standard therapy, 30 - only the standard therapy for 4 months. Patients treated with MO in the complex therapy were characterized by a statistically significant reduction in clinical signs of magnesium deficiency: the weakening of seizures (odds ratio [OR], 0.2, P = 0.038), reduction of symptoms of arrhythmia (OR, 0.1, P = 0.01); sleep became calmer (OR, 0.3, P= 0.045), and blood pressure was normalized. Significant decrease of OSWESTRY and Visual Analog Scale pain scores was an important result in patients treated with the MO. Thus, the use of MO (drug Magnerot ®) in the combined therapy provides more effective rehabilitation of patients after excision of hernia of intervertebral disk.

degenerative spine diseases, hernia of intervertebral disc, surgery, magnesium orotate, Magnerot