Alkogol'naya bolezn' pecheni: immunologicheskie mekhanizmy patogeneza - novyy vzglyad na tselesoobraznost' primeneniya S-adenozil-L-metoinina
- Authors: Nikitin I.G1, Baykova I.E1, Gogova L.M1, Kislyakov V.A1, Volynkina V.M1
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Affiliations:
- Issue: No 13 (2012)
- Pages: 51-56
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/279743
- ID: 279743
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Abstract
The article considers the mechanisms of development of alcoholic liver disease (ALD); morphological and clinical characteristics of the different forms of the disease are presented. The significance of immune disorders in the pathogenesis of ALD, including the neoantigen formation and production of autoantibodies, is discussed. The data on the significance of cytokine disorders in the pathogenesis of ALD and promising approaches to the treatment are represented. Difficulties in the treatment of special groups of ALD patients, which include persons with liver cirrhosis and attacks of acute alcoholic hepatitis, are emphasized. The use of S-adenosyl-L-methionine (Heptral), a preparation with a broad spectrum of hepatoprotective properties, including anti-cytokine activity, can give effectual help in their treatment.
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