Mukoaktivnye preparaty i obostrenie khronicheskoy obstruktivnoy bolezni legkikh (fokus na karbotsistein)
- Authors: Sinopal'nikov A.I1
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Affiliations:
- Issue: No 15 (2012)
- Pages: 22-27
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/279886
- ID: 279886
Cite item
Abstract
In recent years, increased interest in mucoactive drugs is caused by two reasons: better understanding of the pathophysiology of chronic obstructive pulmonary disease (COPD); in particular, it was found that the lungs are constantly secrete a variety of oxidants produced endogenously as a result of metabolic reactions, and exogenously in response to aeropollutant exposure, including components of tobacco smoke; and evidence that some of mucoactive drugs (N-acetylcysteine, carbocisteine) have antioxidant properties. In this context, special attention should be paid to carbocisteine (S-carboxymethylcysteine, also available carbocisteine lysine salt - S-carboxymethylcysteine lysinate) - mucoregulatory drug with anti-oxidant and anti-inflammatory properties, which are now widely used in the treatment of patients with COPD. The numerous clinical studies suggest that long-term (6-12-month) use of drug in COPD patients is accompanied by reduction of frequency of disease exacerbations and improvement of quality of life for patients.
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References
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