Delayed-onset neutropenia associated with rituximab therapy
- Authors: Alekseeva Y.A1, Vabishchevich R.I1
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Affiliations:
- Issue: No 18 (2012)
- Pages: 62-65
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/280002
- ID: 280002
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Abstract
Delayed-onset neutropenia (DON) is a rare condition often occurring without a high risk of infection. Genesis of this condition is poorly understood; release of antineutrophil antibodies, inhibition of neutrophils through the formation of large granular lymphocytes, granulocytes maturation change after reconstitution of B-cell lines, and cytokine desregulation are considered as possible mechanisms of development. In some cases, DON occurs in patients receiving rituximab. Currently, clinical experience indicate the possibility of reinitiation of therapy with rituximab after resolution of DON.
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References
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