Khronicheskaya persistiruyushchaya bol', obuslovlennaya revmaticheskimi zabolevaniyami, u lyudey starshego vozrasta


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Chronic persistent pain, associated with degenerative-dystrophic rheumatic diseases (eg osteoarthrosis - OA) in elderly patients, can cause difficulties for a practicing physician at the stages of its recognition, diagnosis, treatment, and monitoring the effectiveness and tolerability of pharmacological agents used. In OA, non-steroidal antiinflammatory drugs (NSAIDs) are the most common drugs used. An empirical approach to the selection of the preparation and dose leads to necessity for changes of NSAIDs. In this connection, NSAID with different dose delivery systems for their combined use (topically, orally or by injection) are preferable, because the simultaneous use of two agents from different chemical groups is contraindicated. The drug ketoprofen (Ketonal) meets these requirements. The variety of dose delivery systems of Ketonal provides reliable pain relief with low risk of side effects against the background of its long-term use.

Full Text

Restricted Access

About the authors

E. G Zotkin

References

  1. Molony SL, Kobayashi M, Holleran EA, Mezey M. Assessing pain as a fifth vital sign in long-term care facilities. J Gerontol Nurs 2005;31:16-24.
  2. Davis MP, Srivastava M. Demographics, assessment and management of pain in the elderly. Drugs Aging 2003:20:23-57.
  3. Zhang W, Moskowitz RW, Nuki G, et al. OARSI recommendations for the management of hip and knee osteoarthritis. Part I: Critical appraisal of existing treatment guidelines and systematic review of current research evidence.Osteoarthritis Cartilage 2007; 15:981-1000.
  4. Andersson HI. Increased mortality among individuals with chronic widespread pain relates to lifestyle factors: a prospective populationbased study. Disabil Rehabil 2009;31:1980-87.
  5. Perrot S. Should we switch from analgesics to the concept of "pain modifying analgesic drugs (PMADS)" in osteoarthritis and rheumatic chronic pain conditions? Pain 2009; 146:229-30.
  6. Raffa R. Pharmacological aspects of successful long-term analgesia. Clin Rheumatol 2006;25:S9-S15.
  7. Raffa R, Clark-Vetri R, Tallarida R, Wertheimer A. Combination strategies for pain management. Expert Opin Pharmacother 2003;4:1697-708.
  8. Hootman JM, Helmick CG. Projections of US prevalence of arthritis and associated activity limitations. Arthritis Rheum 2006;54:226-29.
  9. Hochberg M, Dougados M. Pharmacological therapy of osteoarthritis. Best Pract. Res Clin Rheumatol 2001;15:583-93.
  10. Hazlewood G, van der Heijde DM, Bombardier C. Paracetamol for the management of pain in inflammatory arthritis: a systematic literature review. J Rheumatol 2012;90:11-6.
  11. AGS Panel on Pharmacological Management of Persistent Pain in Older Persons. Pharmacological management of persistent pain in older persons. www.americangeriatrics.org/education/final_ recommendations.pdf, July 3, 2009.
  12. Cepeda M, Camargo F, Zea C, Valencia L. Tramadol for osteoarthritis. Cochrane Datab Syst Rev 2006;(3):CD005522.
  13. McNeil-NSAID Washington D.C. Food and Drug Adminstration [2012, September 9]. http://www. fda.gov/ ohrms/dockets/ac/02/ briefing/3882B2_02_McNeil-NSAID.htm
  14. Ofman J, MacLean C, Straus W, et al. A metaanalysis of severe upper gastrointestinal complications of nonsteroidal antiinflammatory drugs. J Rheumatol 2002;29:804-12.
  15. Boers M, Tangelder M, van Ingen H, Fort J, Goldstein J. The rate of NSAID-induced endoscopic ulcers increases linearly but not exponentially with age: a pooled analysis of 12 randomised trials. Ann Rheum Dis 2007; 66:417-18.
  16. Trelle S, Reichenbach S, Wandel S, et al. Cardiovascular safety of non-steroidal antiinflammatory drugs: network meta-analysis. BMJ 2011;342:7086.
  17. Turner MK, Hooten WM, Schmidt JE, et al. Prevalence and clinical correlates of vitamin D inadequacy among patients with chronic pain. Pain Med 2008;9:979-84.
  18. Kroenke K, Bair MJ, Damush TM, et al. Optimized antidepressant therapy and pain self-management in primary care patients with depression and musculoskeletal pain: A randomized controlled trial. JAMA 2009;301:2099-110.
  19. Moore R, Straube S, Wiffen P, Derry S. McQuay H. Pregabalin for acute and chronic pain in adults. Cochrane Datab Syst Rev 2009;8(3):CD007076.
  20. Lee YH, Woo JH, Choi SJ, et al. Effect of glucosamine or chondroitin sulfate on the osteoarthritis progression: A meta-analysis. Rheumatol Int 2010;30:357-63.

Supplementary files

Supplementary Files
Action
1. JATS XML

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies