Eribulin – novyy mikrotrubochkovyy ingibitor dlya lecheniya metastaticheskogo raka molochnoy zhelezy


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Abstract

According to current guidelines, there is no single standard of medical care for patients with metastatic breast cancer (BC) who have received prior therapy. Eribulin mesylate has recently been approved in Russia for the treatment of patients with locally advanced or metastatic breast cancer in whom progression occurred after the application of at least two chemotherapy regimens, which was administered for advanced disease and which included anthracyclines and taxanes. Due to the unique mechanism of action, eribulin have higher anti-tumor activity compared with other microtubule inhibitors, as well as potential for overcoming chemoresistance as a substantial clinical problem. Approval of Eribulin by the European Medicines Agency in 2011 was based on the results of the phase III EMBRACE trial, the first study that demonstrated a significant increase in survival in patients with advanced breast cancer previously treated with anthracyclines and taxanes. Moreover, the data obtained in the study 301, support the feasibility of use of eribulin in women with short-term duration of treatment compared with EMBRACE participants. Data subanalyses also indicate that in certain groups of patients, including those with triple negative phenotype of tumor, eribulin effect on overall survival could be more pronounced than in the general population of patients. In addition to advantages in efficiency, eribulin is well tolerated, has clinically acceptable and controlled side-effect profile. This review describes eribulin, including its mechanism of action and key data on efficacy and safety according phase III trials.

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M. B Stenina

Email: mstenina@mail.ru

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