ИСПОЛЬЗОВАНИЕ НЕСТЕРОИДНЫХ ПРОТИВОВОСПАЛИТЕЛЬНЫХ СРЕДСТВ И РИСК КАРДИОВАСКУЛЯРНЫХ ОСЛОЖНЕНИЙ


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Аннотация

Нестероидные противовоспалительные средства (НПВС) увеличивают риск кардиоваскулярных осложнений и кардиоваскулярной смертности независимо от их селективности в отношении ингибиции циклооксигеназы-2 (ЦОГ-2). В статье обобщены данные рандомизированных контролируемых и наблюдательных исследований по кардиоваскулярной безопасности НПВС. Среди селективных ингибиторов ЦОГ-2 наименьшим риском развития инфаркта миокарда обладает мелоксикам. Среди неселективных НПВС наименьшим кардиоваскулярным риском обладает напроксен. Тем не менее развитие любого кардиоваскулярного осложнения возможно при использовании любого НПВС, особенно лицами с коморбидными сердечно-сосудистыми заболеваниями. В связи с этим рекомендации использования как можно более низких доз НВПС и в более короткие сроки представляются весьма обоснованными.

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Н. В Чичасова

ГБОУ ВПО «Первый МГМУ им. И.М. Сеченова» Минздрава России, Москва

д.м.н., проф. кафедры ревматологии ФППОВ

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