Abdominal'nye boli: ot patogeneza k lecheniyu


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Abstract

The article considers the characteristics of the two main types of abdominal pain (neuropathic and visceral) and the mechanisms of their development. The stages of reduction of muscle fibers, as well as central and local mechanisms of their regulation are presented. The role of opioid system and the functional state of interstitial Kayal cells in the regulation of gastrointestinal motility, visceral sensitivity and the formation of a antinoceptive mechanisms of pain control is discussed. It is noted that trimebutin is an effective drug for the treatment of patients with abdominal pain syndrome, it has antispasmodic and prokinetic effects, and reduces visceral hypersensitivity.

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