Genital'nye mikoplazmy (U. parvum, U. urea-lyticum, M. hominis, M. genitalium) v akusherskoy praktike


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Abstract

The prospective analysis of course of pregnancy, childbirth and the postpartum period in 677 pregnant women who were screened for the presence of vulvovaginal and cervical infections, and early neonatal period in infants from these mothers was performed. Genital mycoplasmas (GM) in the vagina and cervix were found in 304 patients, accounting for 44.9% of all women surveyed. In the vast majority (232; 76.3%) of pregnant women, GM in the lower genital tract were combined with other opportunistic pathogens. Only in 72 (10.6%) cases, GM were isolated as a monoculture or in combination with only Lactobacillusspp. It has been shown that in pregnant women colonization of the lower genital tract with opportunistic pathogens is an important risk factor for premature labor, premature discharge of amniotic fluid, low birth weight infants (<2500 g), postpartum endometritis and wound infection. Obviously, GM do not have vital importance in the pathogenesis of adverse outcomes of pregnancy, childbirth, postpartum and early neonatal period.

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  1. Анкирская А.С., Муравьева В.В. Опыт микробиологической диагностики оппортунистических инфекций влагалища. Клиническая микробиология и антимикробная терапия. 2001;3(2):170-94.
  2. Асцатурова О.Р. Диагностика и лечение вульвовагинальной и хламидийной инфекции в III триместре беременности. Дисс. канд. мед. наук. М., 1998.
  3. Башмакова М.А., Савичева А.М. Генитальные микоплазмы и микоплазменные инфекции. Урогенитальные инфекции. 2006;2(4):24-30.
  4. Бенькович А.С., Шипицына Е.В., Савичева А.М. Инфекция, вызванная M. genitalium: клиника, диагностика, лечение. Гинекология. 2009;11(3):4-9.
  5. Лаврова Д.Б., Гасанова Т.А. Частота распространения, диагностика и клиническое течение микоплазмозов у новорожденных. Тез. докл. Саратов, 2000. С. 98-100.
  6. Никонов А.П., Асцатурова О.Р., Чилова Р.А., Ищенко А.И., Рафальский В.В. Инфекции в акушерстве и гинекологии: диагностика и антимикробная химиотерапия: Пособие для врачей. М., 2006. 42 с.
  7. Сухорукова М.В. Ureaplasma Urealyticum: клиническое значение при урогенитальных инфекциях, подходы к диагностике и терапии. Consilium Med. 2009;11(7):42-5.
  8. Alfa M.J., Embree J.E., Degagne P., Olson N., Lertzman J., Macdonald K.S., Macdonald N.T., Hall P.F. Transmission of Ureaplasma urealyticum from mothers to full and preterm infants. Pediatr. Infect. Dis. J. 1995;14(5):341-45.
  9. Bergeron M.G., Ke D., Mеnard C., Picard F.J., Gagnon M., Bernier M., Ouellette M., Roy P.H., Marcoux S., Fraser W.D. Rapid detection of group B streptococci in pregnant women at delivery. N. Eng. J. Med. 2000;343(3):175-79.
  10. Goldenberg R.L., Andrews W.W., Goepfert A.R., Faye-Petersen O., Cliver S.P., Carlo W.A., Hauth J.C. The Alabama Preterm Birht Study: umbilical cord blood Ureaplasma urealyticum and Mycoplasma hominis cultures in very preterm newborn infants. Am. J. Obstetr. Gynecol. 2008;198(1):1-3.
  11. Crouse I.T., Odrezin G.T., Gutter G.R., Reese J.M., Hamrick W.B., Waites K.B., Cassell G.H. Cassell. Radiographic changes associated with tracheal isolation of Ureaplasma urealyticum from neonates. Clin. Infect. Dis. 1993;17(Suppl. 1):S122-30.
  12. Dallo S.F., Baseman J.B. Intracellular DNA replication and long-term survival of pathogenic mycoplasmas. Microbiol. Pathol. 2000; 29:301-09.
  13. Escenbach D.A. Ureaplasma urealyticum and premature birth. Clin. Infect. Dis. 1993;17(1):100-06.
  14. Eschenbach D.A., Gravett M.G., Chen K.C., Hoyme U.B. Holmes K.K. Bacterial vaginosis during pregnancy: an association with prematurity and postpartum complication. Scand. J. Urol. Nephrol. 1984;86(Suppl.):213-22.
  15. Gravett M.G., Escenbach D.A. Possible role of Ureaplasma urealyticum in preterm premature rupture of fetal membranes. Pediatr. Infect. Dis. 1986;5(6):253-57.
  16. Haggerty C.L., Brandie D.T. Mycoplasma genitalium: An Emerging Cause of Pelvic Inflammatory Diseases. Infect. Dis. in Obstet. and Gynecol. 2011;2011:1-9.
  17. Hillier S.L., Nugent R.P., Eschenbach D.A., Krohn M.A., Gibbs R.S., Martin D.H., Cotch M.F., Edelman R., Pastorek J.G. II, et al. Association between bacterial vaginosis and preterm delivery of a low-birt-weight infant. N. Engl. J. Med. 1995;333:1737-42.
  18. Horner P.J., Gilroy C.B., Thomas B.J., Naidoo R.O., Taylor-Robinson D. Association of Mycoplasma genitalium with acute nongonococcal urethritis. Lancet. 1993;342:582-85.
  19. Jensen J.S. Mycoplasma genitalium infecnion. Dan. Med. Bull. 2006;53(1):1-27.
  20. Jensen J.S., Blom J., Lind К. Intracellular location of Mycoplasma genitalium in cultured Vero cells as demonstrated by electron microscopy. Int. J. Exp. Pathol. 1994;75:91-8.
  21. Waites K.B., Katz B., Schelonka R.I. Mycoplasmas and Ureaplasmas as Neonatal Pathogens. Clin. Microb. Rev. J. 2005;18:757-89.
  22. Kirchner L., Helmer H., Heinze G., Wald M., Brunbauer M., Weninger M., Zaknun D. Amnionitis with Ureaplasma urealyticum or other microbes leads to increased morbidity and prolonged hospitalization in very low birth infants. Eur. J. Obstetr. Gynecol. Reprod. Biol. 2007;134(5):44-50.
  23. Kong F., Ma L., James J., Gordon S., Gilbert G.L. Species identification and subtyping of Ureaplasma urealyticum using PCR - based assay. J. Clin. Microbiol. 2000;38(3):1175-79.
  24. Labb A.C., Frost E., Deslandes S., Mendonca A.P., Alves A.C., Pepin J. Mycoplasma genitalium is not associated with adverse outcomes of pregnancy in Guinea-Bissau. Sex. Transm. Inf. 2002;78(4):289-91.
  25. Lo S.C., Shih J.W., Yang N.Y., Ou C.Y., Wang R.Y. A novel virus-like infectious agents in patients with AIDS. Am. J. Trop. Med. Hyg. 1989;40:213-26.
  26. Mernaugh G.R., Dallo S.F., Holt S.C., Baseman J.B. Properties of adhering and nonadhering populations of Mycoplasma genitalium. Clin. Infect. Dis. 1993;17(Suppl. 1):S69-78.
  27. Oakeshott P., Hay P., Taylor-Robinson D., Hay S., Dohn B., Kerry S., Jensen J.S. Prevalence of Mycoplasma genitalium in early pregnancy and relationship between its presence and pregnancy outcome. BJOG. 2004;111(12):1464-67.
  28. Randelovic G., Kocic B., Miljkovic-Selimovic B., Mladenovic-Antic S., Stojanovic P., Stefanovic M. High-density cervical Ureaplasma urealyticum colonization in pregnant women as a risk factor for premature rupture of membranes. Vojnosanit Pregl. 2006;63(8):737-41.
  29. Rosenstein I.J., Morgan D.J., Sheehan M., Lamont R.F., Taylor-Robinson D. Bacterial vaginosis in pregnancy: distribution of bacterial species in different gram-stain categories of the vaginal flora. J. Med. Microbiol. 1996; 45:120-26.
  30. Schuchat A. Epidemiology of group B streptococcal disease in the United States: shifting paradigms. Clin. Microb. Rev. 1998; 11(3):497-513.
  31. Shames M., George R.B., Holliday W.B., Rasch J.R., Mogabgab W.J. Comparison of antibiotics in the treatment of mycoplasmal pneumonia. Arch. Intern. Med. 1970;125:680-84.
  32. Taylor-Robinson D. The role of mycoplasmas in pregnancy outcome. Best Practice and Res. Clin. Obstetr. Gynecol. 2007;21(3):425-38.
  33. Witt A., Berger A., Gruber C.J., et al. Increased intrauterine frequency of Ureaplasma urealyticum in women with preterm labor and premature rupture of the membranes and subsequent cesarean delivery. Am. J. Obstetr. Gynecol. 2005;193(5):1663-69.

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