Effektivnost' vaktsinatsii protiv grippa vo vremya beremennosti

The study was aimed to the evaluation of the effect of preventive influenza vaccination during pregnancy on some gestational indicators. The study included 110 patients. Group I (main) consisted of 58 pregnant women who underwent influenza vaccination at 23-35 weeks of gestation using trivalent inactivated subunit vaccine. Group II (control) included 52 patients who were not subjected to influenza vaccination. Following assessments were performed: ultrasound fetometry, analysis of serum α-fetoprotein, human chorionic gonadotropin, trophoblastic β1 -glycoprotein contents. Analysis of clinical and laboratory data of pregnant women vaccinated with subunit vaccine showed no destabilizing changes of homeostasis after vaccination. Post-vaccination period was accompanied by minor local and systemic reactions. Manifestations of influenza were noted in 3 (5.1%) patients of Group I, and in 16 (30.8%) patients of group II (p<0.05). Dysfunction of the fetoplacental complex was detected in 2 (3.4%) and 5 (9.6%) pregnant women in group I and group II, respectively (p<0.05). The results showed that influenza vaccination in pregnant women provides a reduction in the incidence of acute respiratory viral diseases, thereby reducing the frequency of functional disorders of the fetoplacental complex.

influenza, pregnancy, preventive vaccination, vaccine