Potentials for the use of lornoxicam in the treatment of osteoarthrosis


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Osteoarthrosis is the most common cause of arthralgia and functional disorders of the joints in the older age group. Non-steroidal antiinflammatory drugs (NSAIDs) still play an important role in the treatment of this disease. Lornoxicam is a modern NSAID from the group of oxycams, it has a strong analgesic and anti-inflammatory actions. A distinctive feature of the drug is a short half-life, which makes it well-tolerated drug with relatively low incidence of side effects. To date, significant experience in the application of lornoxicam in patients with both acute and chronic pain is accumulated. The high efficacy of the drug is proved in a number of foreign and domestic research when it was used for the relief of clinical manifestations of osteoarthrosis. In patients with osteoarthrosis, lornoxicam is effective in the same way as diclofenac, but is superior to diclofenac in the short and long-term use according some indicators of safety.

Full Text

Restricted Access

About the authors

N. M Bulanov

P. I Novikov

Email: novikov-pavel@mail.ru

References

  1. Fibel K.H., Hillstrom H.J., Halpern B.C. State-of-the-Art management of knee osteoarthritis. World J. Clin. Cases. 2015;3(2):89-101.
  2. Cutolo M., Berenbaum F., Hochberg M., et al. Commentary on recent therapeutic guidelines for osteoarthritis. Semin. Arthritis Rheum. 2014 Dec 24. pii: S0049-0172(14)00326-6.
  3. Pruss T.P., Stroissnig H., Radhofer-Welte S., Wendtlandt W., Mehdi N., Takacs F., Fellier H. Overview of the pharmacological properties, pharmacokinetics and animal safety assessment of lornoxicam. Postgrad. Med. J. 1990;(Suppl. 4):S18-215
  4. Ferber H.P., Maleschitz P., Binder D. Chlortenoxicam, a new NSAID, prevents the arachidonic acid induced toxicity [abstractA387]. 2nd World Conference on Inflammation, Antirheumatics, Analgesics, Immunomodulators; 1986 Mar 19-22; Monte Carlo.
  5. Berg J., Christoph T., Widerna M., et al. Isoenzyme-specific cyclooxygenase inhibitors: a whole cell assay system using the human erythroleukemic cell line HEL and the human monocytic cell line Mono Mac 6. J. Pharmacol. Toxicol. Methods 1997;37:179-86.
  6. Bias P. Efficacy and safety of lornoxicam (8mg b.i.d.) in comparison with placebo in patients with osteoarthritis of the knee: a four-week, randomized, prospective multicentre, doubleblind, placebocontrolled, parallel-group phase IIb study (study CT 94). Nycomed Pharma A/S, 1995.
  7. Lorenz I.H., Egger K., Schubert H., Schnörer C., Tiefenthaler W., Hohlrieder M., Schocke M.F., Kremser C., Esterhammer R., Ischebeck A., Moser P.L., Kolbitsch C. Lornoxicam characteristically modulates cerebral pain-processing in human volunteers: a functional magnetic resonance imaging study. Br. J. Anaesth. 2008;100:827-33.
  8. Korkmaz Dilmen O., Tunali Y., Cakmakkaya O.S., Yentur E., Tutuncu A.C., Tureci E., Bahar M. Efficacy of intravenous paracetamol, metamizol and lornoxicam on postoperative pain and morphine consumption after lumbar disc surgery. Eur. J. Anaesthesiol. 2010;27:428-32.
  9. Patel A., Skelly A.M., Kohn H., Preiskel H.W. Double-blind placebo-controlled comparison of the analgesic effects of single doses of lornoxicam and aspirin in patients with postoperative dental pain. Br. Dent. J. 1991;170:295-99.
  10. Pektas Z.O., Sener M., Bayram B., Eroglu T., Bozdogan N., Donmez A., Arslan G., Uckan S. A comparison of pre-emptive analgesic efficacy of diflunisal and lornoxicam for postoperative pain management: a prospective, randomized, single-blind, crossover study. Int. J. Oral.Maxillofac. Surg. 2007;36:123-27.
  11. Zhang Z., Huang G. Intra-articular lornoxicam loaded PLGA microspheres: enhanced therapeutic efficiency and decreased systemic toxicity in the treatment of osteoarthritis. Drug. Delivery. 2012; 19(5):255-63.
  12. Adams S.S. Non-steroidal anti-inflammatory drugs, plasma half-lives and adverse reactions [letter]. Lancet. 1987;II:1204-05.
  13. Brittain H.G. Profiles of Drug Substances, Excipients and Related Methodology. 2011;36:206-19.
  14. Warrington S.J., Debbas N.M., Farthing M., Hor ton M., Johnston A., Thillainayagam A., Turner P., Ferber H. Lornoxicam, indomethacin and placebo: comparison of effects on faecal blood loss and upper gastrointestinal endoscopic appearances in healthy men. Postgrad. Med. J. 1990;66:622-26.
  15. Kullich W., Klein G., Pollmann G. Influence of lornoxicam on serum pepsinogen levels. Postgrad. Med. J. 1990;66(Suppl. 4):S46-8.
  16. Agundez J.A., Garcia-Martin E., Martinez C. Genetically based impairment in CYP2C8- and CYP2C9-dependent NSAID metabolism as a risk factor for gastrointestinal bleeding: is a combination of pharmacogenomics and metabolomics required to improve personalized medicine? Expert. Opin. Drug. Metab. Toxicol. 2009;5:607-20.
  17. Felfernig M., Salat A., Kimberger O., Gradisek P., Müller M.R., Felfernig D. Preemptive analgesia by lornoxicam - an NSAID significantly inhibits perioperative platelet aggregation. Eur. J. Anaesthesiol. 2008;25:726-31.
  18. Mowafi H.A., Telmessani L., Ismail S.A., Naguib M.B. Preoperative lornoxicam for pain prevention after tonsillectomy in adults. J Clin Anesth 2011; 23:97-101.
  19. Mazaris E.M., Varkarakis I., Chrisofos M., Skolarikos A., Ioannidis K., Dellis A., Papatsoris A., Deliveliotis C. Use of nonsteroidal anti-inflammatory drugs after radical retropubic prostatectomy: a prospective, randomized trial. Urology. 2008;72:1293-97.
  20. Warrington S.J., Dawnay A., Johnston A., Saul S., Turner P., Ferber H.P. Chlortenoxicam and renal function of normal human volunteers [letter]. Hum. Toxicol. 1989;8:53-4.
  21. Cunningham J., Wilkie M., Beer J., et al. The effect of renal dysfunction on the pharmacokinetic profile of lornoxicam. Hafslund. Nycomed. Pharma AG. (Data on file).
  22. Kidney Disease: Improving Global Outcomes (KDIGO) CKD WorkGroup. KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney international, Suppl. 2013;3:1-150.
  23. Krum H., Swergold G., Gammaitoni A., Peloso P.M., Smugar S.S., Curtis S.P., Brater D.C., Wang H., Kaur A., Laine L., Weir M.R., Cannon C.P. Blood pressure and cardiovascular outcomes in patients taking nonsteroidal antiinflammatory drugs. Cardiovasc. Ther. 2012;30:342-50.
  24. Charlot J. Long term efficacy and tolerability of lomoxicam in elderly patients with rheumatoid arthritis or osteoarthritis: a multicenter, open study. Hafslund Nycomed Pharma AG. (Data on file)
  25. Berry H., Bird H.A., Black C., Blake D.R., Freeman A.M., Golding D.N., Hamilton E.B., Jayson M.I., Kidd B., Kohn H., et al. A double blind, multicentre, placebo controlled trial of lornoxicam in patients with osteoarthritis of the hip and knee. Ann. Rheum. Dis 1992;51:238-42.
  26. Hafslund Nycomed Pharma AG. Efficacy and safety of lornoxicam (8mg bj.d) in comparison with placebo in patients with osteoarthritis of the knee - a four-week, randomized, prospective multicentre, double-blind, placebo-controlled, parallel group phase IIb study. Hafslund Nycomed Pharma AG. (Data on file).
  27. Kidd B. A multicentre, randomised, double-blind study comparing lornoxicam with dicIofenac in osteoarthritis. Hafslund Nycomed Pharma AG. (Data on file).
  28. Goregaonkar A., Mathiazhagan K.J., Shah R.R., Kapoor P.S., Taneja P., Sharma A., Bolmall C., Baliga V.P. Comparative assessment of the effectiveness and tolerability of lornoxicam 8 mg BID and diclofenac 50 mg TID in adult indian patients with osteoarthritis of the hip or knee: A 4-week, double-blind, randomized, comparative, multicenter study. Curr. Ther. Res. Clin. Exp. 2009;70(1):56-68.
  29. Бадокин В.В. Значение воспаления в развитии и течении остеоартроза. Consilium medicus. 2009;11(9):915.
  30. Ревматология: национальное руководство / Под ред. Е.Л. Насонова, В.А. Насоновой. М., 2010. 720 с.
  31. Хрипунова И.Г., Хрипунова А.А., Мнакацанян С.Г. Ксефокам при купировании болевого синдрома у пациентов с остеоартрозом. Научнопрактическая ревматология. 2006;2:119.
  32. Наумов А.В., Верткин А.Л., Шамуилова М.М., Мендель О.И., Семенов П.А. Стратификация риска и стратегические решения фармакотерапии остеоартроза в терапевтической практике. Справочник поликлинического врача. 2009;5:38-45.
  33. Еременко А.А., Сорокина Л.С., Аветисян М.И. Сравнительная оценка кетопрофена и лорноксикама при послеоперационном обезболивании у кардиохирургических больных. Кардиология и сердечно-сосудистая хирургия. 2009;2(6):72-7.
  34. Головач И.Ю., Семенив И.П., Чипко Т.М., Лазоренко Е.А. Эффективность лорноксикама в лечении синовита коленных суставов у пациентов остеоартритом. Травма. 2014;15(2):29-32.

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2015 Bionika Media

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies