Opyt kombinirovannogo lecheniya bol'nykh kolorektal'nym rakom s izolirovannymi metastazami v pecheni


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The article presents the results of the combined treatment of 60 colorectal cancer patients with isolated liver metastases, combining surgery with perioperative chemotherapy. Proposed treatment algorithm has allowed to achieve high survival rates in patients of the study group. Clinical and morphological characteristics with the greatest prognostic value are discussed.

Full Text

Restricted Access

About the authors

E. V Chernoglazova

Email: ev-onco@mail.ru

G. V Vyshinskaya

I. V Sagaydak

L. E Rotobel'skaya

K. A Vorontsova

References

  1. Патютко Ю.И.,Сагайдак И.В., Котельников А.Г., Поляков А.Н., Чучуев Е.С., Пылев А.Л., Чистякова О.В., Шишкина Н.А. Резекция печени: современные технологии при опухолевом поражении. Анналы хирургической гепатологии. 2010; 15(2):10-7.
  2. Kato T., Yasui К., Hirai Т., Kanemitsu Y., Mori T., Sugihara K., Mochizuki H., Yamamoto J. Therapeutic results for hepatic metastasis of colorectal cancer with special reference of effectiveness of hepatectomy: analysis of prognostic factors for 763 cases recorded at 18 institutions. Dis. Colon. Rectum. 2003;46:22-31.
  3. Nordlinger B, Van Cutsem E., Rougier P., Köhne C.H., Ychou M., Sobrero A., Adam R., Arvidsson D., Carrato A., Georgoulias V., Giuliante F., Glimelius B., Golling M., Gruenberger T., Tabernero J., Wasan H., Poston G.; European Colorectal Metastases Treatment Group. Does chemotherapy prior to liver resection increase the potential for cure in patients with metastatic colorectal cancer? A report from the European colorectal metastases treatment group. Eur. J. Cancer. 2007;43(14):2037-45
  4. Pawlik T.M., Schulick R.D., Choti M.A. Expanding criteria for resectability of colorectal liver metastases. Oncologist. 2008;13(1):51-64.
  5. Schmoll H.J., Van Cutsem E., Stein A., et al. ESMO consensus guidelines for management of patients with colon and rectal cancer: a personalized approach to clinical decision making. Ann. Oncol. 2012;23(10):2479-516.
  6. Agrawal N., Fowler A.L., Thomas M.G. The routine use of intraoperative ultrasound in patients colorectal cancer improves the detection of hepatic metastases. Colorectal. Dis. 2006;8:192-94.
  7. Kulig J., Popiela T., Klek S., Milanowski W., Kolodziejczyk P., Szybinski P., Richter P. Intraoperative ultrasonography in detecting and assessment of colorectal liver metastases. Scand. J. Surg. 2007;96:51-5.
  8. Mazzoni G., Napoli A., Mandetta S., et al. Intra-operative ultrasound for detection of liver metastases from colorectal cancer. S. Liver Int. 2008;28:88-94.
  9. Aloia T.A., Vauthey J.N., Loyer E.M., et al. Resection of colorectal liver metastases. Arch. Surg. 2006;141:460-67.
  10. Karoui M., Penna C., Amin-Hashem M., Mitry E., Benoist S., Franc B., Rougier P., Nordlinger B. Influence of preoperative chemotherapy on the risk of major hepatectomy for colorectal liver metastases. Ann. Surg. 2006;243:1-7.
  11. Патологоанатомическая диагностика опухолей человека/Под ред. Н.А. Краевского. Руководство для врачей в 2 томах. М., 1993. С. 134-35.
  12. Aloia T.A., Sebagh M., Plasse M., Karam V., Levi F., Giacchetti S., Azoulay D., Bismuth H., Castaing D., Adam R. Liver histology and surgical outcomes after preoperative chemotherapy with fluorouracil plus oxaliplatin in colorectal cancer liver metastases. J. Clin. Oncol. 2006; 24:4983-90.
  13. Hubert C., Fervaille C., Sempoux C., Horsmans Y., Humblet Y., Machiels J.P., Zech F., Ceratti A., Gigot J.F. Prevalence and clinical relevance of pathological hepatic changes occurring after neoadjuvant chemotherapy for colorectal liver metastases. Surgery. 2010;147(2):185-94.
  14. Kishi Y., Zorzi D., Contreras C.M., Maru D.M., Kopetz S., Ribero D., Motta M., Ravarino N., Risio M., Curley S.A., Abdalla E.K., Capussotti L., Vauthey J.N. Extended preoperative chemotherapy does not improve pathologic response and increases postoperative liver insufficiency after hepatic resection for colorectal liver metastases. Ann. Surg. Oncol. 2010;17(11):2870-76.
  15. Rubbia-Brandt L., Lauwers G.Y., Wang H., Majno P.E., Tanabe K., Zhu A.X., Brezault C., Soubrane O., Abdalla E.K., Vauthey J.N., Mentha G., Terris B. Sinusoidal obstruction syndrome and nodular regenerative hyperplasia are frequent oxaliplatin-associated liver lesions and partially prevented by bevacizumab in patients with hepatic colorectal metastasis. Histopathology. 2010;56(4):430-39.
  16. Choti M.A., Sitzmann J.V., Tiburi M.F., Sumetchotimetha W., Rangsin R., Schulick R.D., Lillemoe K.D., Yeo C.J., Cameron J.L. Trends in long-term survival following liver resection for hepatic colorectal metastases. Ann. Surg. 2002;235(6):759-66.
  17. Tomlinson J.S., Jarnagin W.R., De Matteo R.P., Fong Y., Kornprat P., Gonen M., Kemeny N., Brennan M.F., Blumgart L.H., D'Angelica M. Actual 10-year survival after resection of colorectal liver metastases defines cure. J. Clin. Oncol. 2007;25(29):4575-80.
  18. Tsai M.S., Su Y.H., Ho M.C. Clinico-pathological features and prognosis in resectable synchronous and metachronous colorectal liver metastasis. Ann. Surg. Oncol. 2007;14(2):786-94.
  19. Kanas G.P., Taylor A., Primrose J.N., Langeberg W.J.,KelshM.A.,MowatF.S.,AlexanderD.D., Choti M.A., Poston G. Survival after liver resection in metastatic colorectal cancer: review and meta-analysis of prognostic factors. Clin. Epidemiol. 2012;4:283-301.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2015 Bionika Media