Prognoz bol'nykh kolorektal'nym rakom pri ozhirenii

Currently, there are more than 1.5 billion overweight people, and 500 million obese people in the world. The negative effects of obesity are associated with an increased risk of cancer of various locations, including colorectal cancer (CRC). This was the basis for the evaluation of the effect of the degree and features of deposition of adipose tissue (AT), its metabolic activity on the course of CRC after curative surgery. The material was compiled of data of examination and treatment of 291 patients with CRC (main group) with I, II, III stages of the disease, who have received treatment in the FSBI «Russian Scientific Center of Radiology and Nuclear Medicine» in the period from 1996 to 2014. Results of the study revealed the negative impact of the increase of body mass index on the colorectal cancer prognosis. The features of AT distribution significantly affect the course of the CRC: central obesity worsens the prognosis of the disease. For patients with colorectal cancer, increasing levels of the hormone of adipose tissue - leptin, has a highest predictive value, because it is associated with increased body weight and central obesity. The increase of leptin levels above 30 ng/ml in patients with colorectal cancer dramatically affects the results of treatment and can be used as an additional factor in determining the indications for adjuvant therapy after radical surgery, regardless of the stage of disease.

colorectal cancer, obesity, fat distribution, leptin