Prognoz bol'nykh kolorektal'nym rakom pri ozhirenii


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Currently, there are more than 1.5 billion overweight people, and 500 million obese people in the world. The negative effects of obesity are associated with an increased risk of cancer of various locations, including colorectal cancer (CRC). This was the basis for the evaluation of the effect of the degree and features of deposition of adipose tissue (AT), its metabolic activity on the course of CRC after curative surgery. The material was compiled of data of examination and treatment of 291 patients with CRC (main group) with I, II, III stages of the disease, who have received treatment in the FSBI «Russian Scientific Center of Radiology and Nuclear Medicine» in the period from 1996 to 2014. Results of the study revealed the negative impact of the increase of body mass index on the colorectal cancer prognosis. The features of AT distribution significantly affect the course of the CRC: central obesity worsens the prognosis of the disease. For patients with colorectal cancer, increasing levels of the hormone of adipose tissue - leptin, has a highest predictive value, because it is associated with increased body weight and central obesity. The increase of leptin levels above 30 ng/ml in patients with colorectal cancer dramatically affects the results of treatment and can be used as an additional factor in determining the indications for adjuvant therapy after radical surgery, regardless of the stage of disease.

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参考

  1. Агаджанян Н.А., Чижов А.Я., Ким Т.А. Болезни цивилизации. Экология человека. 2003;4:9.
  2. Аметов А.С. Перспективы развития диабетологии. Тер. архив. 2005;10:5-9.
  3. Бутрова С.А. Висцеральное ожирение -ключевое звено метаболического синдрома. Международный эндокринологический журнал. 2009;2(20).
  4. Дедов И.И. Мельниченко Г.А. Бутрова С.А. Жировая ткань как эндокринный орган. Ожирение и метаболизм. 2006;1.
  5. Дехисси Е.И., Станоевич У.С., Гребенкин Е.Н.,
  6. Станоевич У.С, Дехисси Е.И., Чхиквадзе В.Д. Колоректальный рак при ожирении: патогенетические аспекты. Врач. 2012;8:23-8.
  7. Чхиквадзе В.Д, Станоевич У.С, Дехисси Е.И. и др. Роль адипокинов в прогрессировании колоректального рака. Врач. 2015;6:61-3.
  8. Bhaskaran K. Higher BMI increased risk for 10 common cancers. Lancet. 2014;14:61172-7.
  9. De Pergola G., Silvestris F. Obesity as a Major Risk Factor for Cancer. J. Obesity. 2013;11.
  10. Wolin K.Y., Carson K., Colditz G.A. Obesity and cancer. Oncologist. 2010;15(6):556-65.
  11. World Health Organization. Obesity: preventing and managing the global epidemic. Report of a WHO consultation. Tech. Rep. Ser. 2000;894:1-253.
  12. World Health Organization. Obesity and over weight. Newsletter. 2014;311.
  13. World Health Organization. International Agency for Research on Cancer. GLOBOCAN 2012: Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 2012. 2014.
  14. Yu H., Rohan T. Role of the insulin-like growth factor family in cancer development and progression. J. Natl. Cancer Inst. 2000; 92:1472-89.
  15. Zeyda M., Stulnig T.M. Obesity, inflammation, and insulin resistance-a mini-review. Gerontology. 2009;55:379-86.

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