EFFICIENCY OF ENTEROSGEL IN CORRECTION OF SYSTEMIC ENDOTOXEMIA IN CHILDREN WITH ATOPIC DERMATITIS


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Children with atopic dermatitis have shown an increased plasma levels of endotoxin up to 0.140±0.071 EU/ml (р<0.001), and levels of endotoxin depend on the period of disease severity and activity of the skin process. The presence of systemic endotoxemia in this pathology is an indication for administration of drug Enterosgel (polymethylsiloxane polyhydrate) as a part of the complex antiallergic therapy. This leads to decrease of plasma endotoxin levels by 12 times from 0.142 to 0.012 EU/ml, decline of the acute period by 1.6 times (days) and reduction of the SCORAD index by 5 times. This method of therapy has shown a high efficiency and can be widely used in the treatment of atopic dermatitis.

Full Text

Restricted Access

About the authors

T. G Malanicheva

Kazan State Medical University

Email: tgmal@mail.ru
MD, Prof. at the Department of Propaedeutics of Children’s Diseases and Faculty Pediatrics with a course of Childhood Diseases of the Medical Faculty

B. A Shamov

Kazan State Medical University

References

  1. Yakovlev M. Elements of Endotoxin Theory of Human Physiology and Pathology: «Sistemic Endotoxinemia», «Endotoxin Agression» and « Endotoxin Insuficancy». J. of Endotoxin Research 2000; 2: 120.
  2. Аниховская И.А., Опарина О.Н., Яковлева М.М. и др. Кишечный эндотоксин какуниверсальный фактор адаптации и патогенеза общего адаптационного синдрома. Физиология человека. 2006; 2: 87-91.
  3. Яковлев М.Ю. Элементы эндотоксиновой теории физиологии и патологии человека. Физиология человека. 2003; 3: 154-64.
  4. Вышегуров Я.Х, Аниховская И.А., Батманов Ю.Е., Яковлев М.Ю. Кишечный эндотоксин в патогенезе воспалительной патологии глаза и антиэндотоксиновая составляющая ее лечения. Патол. физиол. и эксперимент. тер. 2007; 1: 12-4.
  5. Таболин В.А., Лазарева С.И., Яковлев М.Ю. Антифосфолипидный синдром: важная роль эндотоксиновой агрессии. Педиатрия. 2001; 5: 80-4.
  6. Чернихова Е.А., Аниховская И.А., Гатауллин Ю.К. и др. Энтеросорбция как важное средство устранения хронической эндотоксиновой агрессии. Физиология человека. 2007; 3: 135-36.

Supplementary files

Supplementary Files
Action
1. JATS XML

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies