EFFECT OF HYPOXIA ON THE LIFE OF TUMOR CELLS AND ITS CORRECTION BY CHEMICAL AGENTS AND DRUGS


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Abstract

In recent years, it is shown that hypoxia is one of the important triggers for tumor formation from genetically transformed cells. Hypoxia induces an activation of nuclear receptor, acting as a cellular oxygen sensor - hypoxia-inducible factor. The review discusses a theoretical background, experimental data and assumptions that the number of agents and drugs that enhance oxygen supply, hinder stabilization and increase the level of hypoxia-inducible factor may potentially inhibit the proliferation of tumor cells and their metastasis.

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About the authors

E. I Astashkin

SRC SBEI HPE «First MSMU n.a. I.M. Sechenov» of RMH

Email: ast-med@mail.ru
Doctor of Biological Scineces, Prof. at the Department of Pathology, Head of the Laboratory of Extreme Conditions Moscow

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