HETEROGENEITY OF DEMENTIA IN PARKINSON'S DISEASE


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Cognitive disorders occur in 90-95% of patients with Parkinson’s disease (PD). According to population-based studies, dementia occurs in 20-40% of patients with PD, according to longitudinal studies - up to 83% of patients. There is no consensus on the causes of dementia in PD. The article presents the results of evaluation of heterogeneity of dementia in 50 PD patients and the possible reasons for its development. The study allowed to identify several types of dementia in PD: 1) with predominantly frontal-subcortical deficits; 2) with predominantly fronto-subcortical deficits and severe behavioral disorders; 3) with severe visual-spatial and neurodynamic disorders, in combination with fluctuations of severity of cognitive disorders; 4) with primary hippocampal-dependent memory impairment. Factors for unfavorable course of dementia and mortality included severe visual-spatial disorders, primary hippocampal-dependent memory impairment in combination with fluctuations of severity of cognitive disorders.

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作者简介

N. Trofimova

FSBEI HE "First MSMU n.a. I.M. Sechenov" of RMH

Moscow

I. Preobrazhenskaya

FSBEI HE "First MSMU n.a. I.M. Sechenov" of RMH

Email: irinasp2@yandex.ru
MD, Associate Professor at the Department of Nervous Diseases and Neurosurgery of the Medical Faculty Moscow

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