OPTIMIZATION OF TREATMENT TACTICS USING TARGETED THERAPY IN METASTATIC AND LOCALLY ADVANCED SMALL CELL LUNG CANCER


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Аннотация

In recent decade, widespread use of molecular genetic research methods revealed new mechanisms of carcinogenesis. Some of these mechanisms became suitable target for therapeutic intervention. Several key signaling pathways, activation of which is directly linked to the proliferation, migration and metastasis of tumor cells, were found. Expression of epidermal growth factor receptors (EGFR) in non-small cell lung cancer (NSCLC) is detected in 85-90% of cases. As a result, EGFR was the first receptor proposed as a target for anticancer therapy. Standard platinum combinations for the treatment of lung cancer have completely exhausted themselves by the end of the twentieth century. The emergence of new anticancer chemotherapeutic agents has created additional possibilities, but none of the known combinations had advantages over others. Only the emergence of targeted therapies has made significant changes in the efficacy of the treatment. Bevacizumab became one of the first targeted therapies registered in NSCLC.

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Авторлар туралы

A. Smolin

Email: smolinGVKG@gmail.com
FSBI «Main Military Clinical Hospital n.a. N.N. Burdenko» of Russian Ministry of Defense Head of the Radiological Center Moscow

E. Kryukov

FSBI «Main Military Clinical Hospital n.a. N.N. Burdenko» of Russian Ministry of Defense Moscow

A. Konev

FSBI «Main Military Clinical Hospital n.a. N.N. Burdenko» of Russian Ministry of Defense Moscow

S. Nikolaeva

FSBI «Main Military Clinical Hospital n.a. N.N. Burdenko» of Russian Ministry of Defense Moscow

Yu. Shamanskaya

FSBI «Main Military Clinical Hospital n.a. N.N. Burdenko» of Russian Ministry of Defense Moscow

A. Gorbacheva

Department of Faculty Surgery №2, FSBEI HE «First MSMU n.a. I.M. Sechenov» of RMH Moscow

A. Matveev

FSBI «Main Military Clinical Hospital n.a. N.N. Burdenko» of Russian Ministry of Defense Moscow

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