NEW REALITIES IN THE TREATMENT OF DISSEMINATED SKIN MELANOMA WITH BRAF MUTATION


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Abstract

Disseminated skin melanoma (DSM) is a malignant neoplasm with one of the highest mortality rates in the world. Low effectiveness of chemotherapy necessitates exploration of new groups of drugs for the treatment of DSM. The discovery of BRAF-mutation and the development of BRAF-inhibitors have significantly improved the results of treatment of the DSM, and changed the quality of life of patients. According to recent studies, the combination of targeted drugs is more effective than monotherapy. Now, combination of BRAF- and MEK-inhibitors (vemurafenib+cobimetinib) can be considered as a new standard for high effective treatment of patients with unresectable or metastatic melanoma with BRAF V600 mutation.

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About the authors

M. E Abramov

FSBI "RORC n.a. N.N. Blokhin" of RMH PhD, Senior Researcher at the Department of Chemotherapy and Combined Therapy of Malignant Tumors Moscow

O. O Gordeeva

FSBI "RORC n.a. N.N. Blokhin" of RMH Moscow

E. I Borisova

FSBI "RORC n.a. N.N. Blokhin" of RMH Moscow

S. L Gutorov

FSBI "RORC n.a. N.N. Blokhin" of RMH Moscow

G. V Vyshinskaya

FSBI "RORC n.a. N.N. Blokhin" of RMH Moscow

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