COMPLEX THERAPY OF IDIOPATHIC INFERTILITY
- Authors: Nashivochnikova N.A1, Krupin V.N1, Selivanova S.A1
-
Affiliations:
- SBEIHPE NizhSMA of RMPH
- Issue: No 1S (2016)
- Pages: 68-71
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/289612
- ID: 289612
Cite item
Open Access
Access granted
Abstract
The article presents the results of the use of the antioxidant complex «Sinergin» in the treatment of 27 men from infertile couples with various forms of idiopathic pathozoospermia and increased level of DNA fragmentation. After application of complex containing ubiquinone, lycopene, /З-carotene, rutin, vitamins C and E for 3 months, analysis of spermograms in patients with idiopathic infertility has revealed the normalization of balance of oxidative and antioxidative processes and a reduction of percentage of DNA fragmentation in sperm cells. It was concluded that inclusion of complex «Sinergin» in the scheme of treatment of idiopathic pathozoospermia with elevated levels of DNA fragmentation in sperm cells is feasible.
Full Text
About the authors
N. A Nashivochnikova
SBEIHPE NizhSMA of RMPH
Email: doml7.doctor@mail.ru
Teaching Assistant at the Department of Urology n.a. E.V. Shakhov
V. N Krupin
SBEIHPE NizhSMA of RMPH
S. A Selivanova
SBEIHPE NizhSMA of RMPH
References
- Воробьева О.А., Воскресенская А.В., Одинцов А.А., Филатов М.В. Мужское бесплодие и нарушение структурной организации хроматина сперматозоидов. Существует ли связь? Пробл. репрод. 2005;6:56-62.
- Воробьева О. А., Филатов М.В.,Леонтьева О.А. Значение анализа организации хроматина ядер сперматозоидов в диагностике мужского бесплодия. Пробл. репрод. 1997;4:23-7.
- Галимов Ш.Н., Громенко Д.С., Галимова Э.Ф., Громенко Ю.Ю., Исхаков И.Р. Влияние L-карнитина на показатели эякулята у мужчин у бесплодных пар. Урология. 2012; 1:47-51.
- Agarwal A., Said Т.М. Role of sperm chromatin abnormalities and DNA damage in male infertility. Hum. Reprod. 2003;19(4):331-45.
- Ahmadi A., Ng S.C. Fertilizing ability of DNA- damaged spermatozoa. J. Exp. Zool. 1999;284: 96-704.
- Gharagozloo ft, Aitken R. The role of sperm oxidative stress in male infertility and the significance of oral antioxidant therapy. Hum. Reprod. 2011;26(7):1628-40.
- Kashou A., Sharma R., Agarwal A. Assessment of oxidative stress in sperm and semen. Methods Mol. Biol. 2013;927:351-61.
- Mancini A., Balercia G. Coenzyme Q (10) in male infertility: physiopathology and therapy. Biofactors. 2011 ;37(5):374-80.
- Nadjarzadeh A., Sadeghi М., Amirjannati N., Vafa M.R., Motevalian S.A,, Gohari M.R., Akhondi M.A., Yavari ft, Shidfar F. Coenzyme Q10 improves seminal oxidative defense but does not affect on semen parameters in idiopathic oligo- asthenoteratozoospermia: a randomized double-blind, placebo controlled trial. J. Endocrinol. Invest. 2011;34(8): 224-28.
- WHO laboratory manual for the examination of human sperm and semem-cervical mucus interaction. WHO, 4 edition. Cambridge: University Press 1999. 128 p.
Supplementary files
