Vaccinal prevention of pneumococcal infection in children with respiratory tuberculosis
- Authors: Drozdenko T.S1, Harit S.M1, Dovgalyuk I.F2
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Affiliations:
- FSBI «Children's Research Clinical Center of Infectious Diseases of the Federal Medical and Biological Agency»
- FSBI «St. Petersburg Scientific Research Institute of Phthisiopulmonology» of RMH
- Issue: No 4 (2017)
- Pages: 50-53
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/289793
- ID: 289793
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Abstract
Children with tuberculosis infection (TI) are at risk for the development of severe invasive pneumococcal infection (PI); furthermore, PI exacerbates the TI. These patients, however, usually do not get the necessary vaccinations before removal from the observation in the phthisiatrician. The problem of immunization of children with TI is not only connected with the fear of vaccination at the hands of parents, but also with the fact that pediatricians have a sense of uncertainty, whether vaccination will reach proper efficiency and does not cause complications or recurrence of the underlying disease. The article presents the results of evaluation of post-vaccination period after immunization with 23-valent polysaccharide pneumococcal vaccine (PPV23) in 35 children aged 3 to 14 years with various manifestations of TI. It is concluded that vaccination with PPV23 is not accompanied by the development of post-vaccination complications and does not cause exacerbation of current TI. The frequency of local and systemic reactions after vaccination does not exceed permissible values. The dynamics of immunological parameters does not confirm immunosuppressive or adverse effects of the vaccine. Immunization against PI is effective in reducing the incidence of acute respiratory infections both in children infected with Mycobacterium tuberculosis and children with respiratory tuberculosis.
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About the authors
T. S Drozdenko
FSBI «Children's Research Clinical Center of Infectious Diseases of the Federal Medical and Biological Agency»PhD, Junior Researcher of the Division of the Prevention of Infectious Diseases
S. M Harit
FSBI «Children's Research Clinical Center of Infectious Diseases of the Federal Medical and Biological Agency»
I. F Dovgalyuk
FSBI «St. Petersburg Scientific Research Institute of Phthisiopulmonology» of RMH
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