INSULIN RESISTANCE AND THYROID HORMONES


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The pathology of the thyroid gland is the second most common pathology among all endocrine diseases. The lack of thyroid hormones affects many functions and processes in the body. One of the manifestations of hypothyroidism is the metabolic-hypothermic syndrome with moderate obesity. In turn, obesity is a component of the metabolic syndrome and is often accompanied by insulin resistance. This review article presents information on the relationship between insulin resistance and thyroid function.

Full Text

Restricted Access

About the authors

A. F Verbovoy

FSBEI HE "Samara State Medical University" of RMH

Samara

Yu. A Dolgikh

FSBEI HE "Samara State Medical University" of RMH

Samara

O. V Kosareva

FSBEI HE "Samara State Medical University" of RMH

Samara

L. A Sharonova

FSBEI HE "Samara State Medical University" of RMH

Samara

I. A Tsanava

FSBEI HE "Samara State Medical University" of RMH

Email: ira.tsamva@gmail.com
Assistam аі the Берайтет оГ Endocrinology Samara

References

  1. Бaлaбoлкин М.И., Клeбaнoвa E. М., Крвминская В.М. Фундаментальная и клиническая тиреодология. М., 2007. 816 с.
  2. Аметов А.С. Избранные лекции по эндокринологии. М., 2012. 540 с.
  3. Дeдoв И.И., Мельниченко Г.А., Фадеев В.В., Эндокринология. Учебник: для студентов медицинских вузов. М., 2012. 432 с.
  4. Svare A., Nilsen T.I., Bjoro T., Asvold B.O., Langhammer A. Serum TSH related to measures of body mass: longitudinal data from the HUNT Study, Norway. Clin. Endocrinol. 2011; 74:769-77.
  5. Волкова А.Р., Беркович О.А., Дора С.В., Дыгун О.Д. Субклинический гипотиреоз и риск артериальной гипертензии у больных ишемической болезнью сердца. Артериальная гипертензия. 2015;21(4):409-15.
  6. Зaхaрoвa С.М., Caвeльeвa Л.В., Фaдeeвa М.И. Ожирение и гипoтирeoз. Ожирение и мeтaбoлизм. 2013;2:54-8.
  7. Pearce E.N. Thyroid hormone and obesity. Curr. Opin. Endocrinol. Diabetes Obes. 2012;19(5):408-13.
  8. Rotondi M., Croce L., Pallavicini C., Manna L.L., Accornero S.M., Fonte R., Magri F., Chiovato L. Bode weight changes in a large cohort of patients subjected to thyroidectomy for a wide spectrum of thyroid diseases. Endocrine Practice. 2014;20(11):1151-58.
  9. Лупaнoв В.П. Ожирение кaк фaктoр риска рaзвития ceрдeчнo-cocудиcтых кaтacтрoф. РМЖ. 2003;6:23-8.
  10. Bray G.Aю, Clearfield M.B., Fintel DюJ., Nelinson D.S. Overweight and obesity: the pathogenesis of cardiometabolic risk. Clin. Cornestrone. 2009;9(4):30-40; discussion 41-2.
  11. Kota S.K., Meher L.K., Krishna S., Modi K. Hypothyroidism in metabolic syndrome. Indian J. Endocrinol. Metab. 2012;16(2):332-33.
  12. Nakajima Yю, Yamada M., Akuzawa M., Ishii S., Masamura Y., Satoh T., Hashimoto K., Negishi M., Shimomura Y., Kobayashi I., Andou Y., Mori M. Subclinical hypothyroidism and indices for metabolic syndrome in Japanese women: one-year follow-up study. J. Clin. Endocrinol. Metab. 2013;98(8):3280-87.
  13. Kowalska I., Borawski J., Nikotajuk A., Budlewski T., Otziomek E., Górska M., Strączkowski M. Insulin sensitivity, plasma adiponectin and sICAM-1 concentrations in patients with subclinical hypothyroidism: response to levothyroxine therapy. Endocrine. 2011;40(1):95-101.
  14. Nada A.M. Effect of treatment of overt hypothyroidism on insulin resistance. World J. Diabetes. 2013;4(4):157-61.
  15. Sridevi A., Vivekanand B., Giridhar G., Mythili A., Subrahmanyan K.A. Insulin resistance and lipid alterations in subclinical hypothyroidism. Indian J. Endocrinol. Metab. 2012;16(2):345-46.
  16. Bonneau G.A., Pedrozo W.R., Berg G. Adiponectin and waist circumference as predictors of insulinresistance in women. Diabetes Metab. Syndr. 2014;8(1):3-7.
  17. Mamtani M., Kulkarni H., Dyer T.D., Almasy L., Mahaney M.C., Duggirala R., Comuzzie A.G., Samollow P.B., Blangero J., Curran J.E. Increased waist circumference is independently associated with hypothyroidism in Mexican Americans: replicative evidence from two large, population-based studies. BMC. Endocr. Disord. 2014;14:46.
  18. Mazaheri T., Sharifi F., Kamali К. Insulin resistance in hypothyroid patients under Levothyroxine therapy: a comparison between those with and without thyroid autoimmunity. J. Diabetes Metab. Disord. 2014;13(1):103.
  19. Guzel S., Seven A., Guzel E.C., Buyuk B., Celebi A., Aydemir B. Visfatin, Leptin, and TNF-α: Interrelated Adipokines in Insulin-Resistant Clinical and Subclinical Hypothyroidism. Endocr. Res. 2013;(Epub ahead of print).
  20. Vyakaranam S., Vanaparthy S., Nori S., Palarapu S., Bhongir A.V. Study of Insulin Resistance in Subclinical Hypothyroidism. Int. J. Health Sci. Res. 2014;4(9):147-53.
  21. Purohit P., Mathur R. Hypertension association with serum lipoproteins, insulin, insulin resistance and C-Peptide: unexplored forte of cardiovascular risk in hypothyroidism. N. Am. J. Med. Sci. 2013;5(3):195-201.
  22. Альтшулер Н.Э. Роль гормонов жировой ткани в развитии кардиоваскулярных заболеваний у женщин с субклиническим гипотиреозом. Дисс. канд. мед. наук. М., 2012.
  23. Posadas-Romero C., Jorge-Galarza E., Posadas-Sánchez R., Acuña-Valerio J., Juárez-Rojas J.G., Kimura-Hayama E., Medina-Urrutia A., Cardoso-Saldaha G.C. Fatty liver largely explains associations of subclinical hypothyroidism with insulin resistance, metabolic syndrome, and subclinical coronary atherosclerosis. Eur. J. Endocrinol. 2014;171(3):319-25.
  24. Misra S., Singh B. Singh B. Insulin resistance and hypothyroidism: a complex relationship in nonalcoholic fatty liver disease. J. Indian Med. Assoc. 2013;111(5):324-6.
  25. Reaven G.M. Role of insulin resistance in human disease. Diabetologia. 1995;38:3-13.
  26. Шварц В. Жировая ткань как эндокринный орган. Проблемы эндокринологии. 2009;1:38-9.
  27. Kokkinos A., Mourouzis I., Kyriaki D., Pantos C., Katsilambros N., Cokkinos D.V. Possible implications of leptin, adiponectin and ghrelin in the regulation of energy homeostasis by thyroid hormone. Endocrine. 2007;32(1):30-2.
  28. Paz-Filho G., Delibasi T., Erol H.K., Wong M.L., Licinio J. Congenital leptin deficiency and thyroid function. Thyroid Res. 2009;2:11.
  29. Iacobellis G., Ribaudo M.C., Zappaterreno A., Iannucci C.V., Leonetti F. Relationship of thyroid function with body mass index, leptin, insulin sensitivity and adiponectin in euthyroid obese women. Clin. Endocrinol. 2005;2:487-91.
  30. Marzullo P., Minocci A., Tagliaferri M.A., Guzzaloni G., Di Blasio A., De Medici C., Aimaretti G., Liuzzi A. Investigations of thyroid hormones and antibodies in obesity: leptin levels are associated with thyroid autoimmunity independent of bioanthropometric, hormonal, and weight-related determinants. J. Clin. Endocrinol. Metab. 2010;95(8):3965-72.
  31. Буркутбаева М.М., Роженцева А.В., Булатов В.И. Эндокринные дизрапторы: возможные причины взаимосвязи субклинического гипотиреоза и гиперлептинемии. Успехи современного естествознания. Материалы конферен ции. 2013;8:39.
  32. Вербовой А.Ф., Вербовая Н.И., Капралова И.Ю. Адипонектин, лептин и другие метаболические показатели у больных гипотиреозом. Фарматека. 2014;10:67-9.
  33. Yildiz B.O., Aksoy D.Y., Harmanci A., Unluturk U., Cinar N., Isildak M., Usman A., Bayraktar M. Effects of L-thyroxine therapy on circulating leptin and adiponectin levels in subclinical hypothyroidism: a prospective study. Arch. Med. Res. 2013;44(4):317-20.
  34. Santini F., Marsili A., Mammoli C., Valeriano R., Scartabelli G., Pelosini C., Giannetti M., Centoni R., Vitti P., Pinchera A. Serum concentrations of adiponectin and leptin in patients with thyroid dysfunctions. J. Endocrinol. Invest. 2004;27(2):5-7.
  35. Iglesias P., Alvarez Fidalgo P., Codoceo R., Diez J.J. Serum concentrations of adipocytokines in patients with hyperthyroidism and hypothyroidism before and after control of thyroid function. Clin. Endocrinol. (Oxf). 2003;59(5):621-29.
  36. Bossowski A., Sawicka B., Szalecki M., Koput A., Wysocka J., Zelazowska-Rutkowska B. Analysis of serum adiponectin, resistin and leptin levels in children and adolescents with autoimmune thyroid disorders. J. Pediatr. Endocrinol. Metab. 2010;23(4):369-77.
  37. Kaplan O., Uzum A.K., Aral H., Uzum G., Tunali V., Demir O., Planci K.N., Kesmezacar O., Ozbey N.C. Unchanged serum adipokine concentrations in the setting of short-term thyroidectomy-induced hypothyroidism. Endocr. Pract. 2012;18(6):887-93.
  38. Альтшулер Н.Э., Петунина Н.А., Николаева А.П., Чернышева Т.В. Сравнительный анализ концентрации гормонов жировой ткани, показателей липидного обмена и инсулинорезистентности при субклиническом гипотиреозе в зависимости от наличия/отсутствия заместительной терапии левотироксином. Клинич. и эксперимент. тиреодология. 2011;7(3):53-8.
  39. Krassas G.E., Pontikides N., Loustis K., Koliakos G., Constantinidis T., Kaltsas T. Resistin levels are normal in hypothyroidism and remain unchanged after attainment of euthyroidism: relationship with insulin levels and anthropometric parameters. J. Endocrinol. Invest. 2006;29(7):606-12.
  40. Aksoy D.Y., Cinar N., Harmanci A., Karakaya J., Yildiz B.O., Usman A., Bayraktar M. Serum resistin and high sensitive CRP levels in patients with subclinical hypothyroidism before and after L-thyroxine therapy. Med. Sci. Monit. 2013;22(19):210-15.
  41. Owecki M., El Ali Z., Wasko R., Nikisch E., Sowinski J. Circulating resistin levels are lower in hypothyroid women but independent from thyroid hormones concentrations. Neuro Endocrinol. Lett. 2008;29(1):131-36.
  42. Вербовая Н.И., Капралова И.Ю., Вербовой А.Ф. Содержание резистина и других адипокинов у больных гипотиреозом. Тер. арх. 2014;10:33-5.
  43. Eke Koyuncu C., Turkmen Yildirmak S., Temizel M., Ozpacaci T., Gunel P., Cakmak M., Ozbanazi Y.G. Serum resistin and insulin-like growth factor-1 levels in patients with hypothyroidism and hyperthyroidism. J. Thyroid. Res. 2013;Article ID 306750. 6 p.
  44. Mazaki-Tovi M., Abood S.K., Kol A., Farkas A., Schenck P.A. Increased serum concentrations of adiponectin in canine hypothyroidism. Vet. J. 2014.
  45. Aragao C.N., Souza L.L, Cabanelas A., Oliveira K.J., Pazos-Moura C.C. Effect of experimental hypo-and hyperthyroidism on serum adiponectin. Metabolism. 2007;56(1):6-11.
  46. Seifi S., Tabandeh M.R., Nazifi S., Saeb M., Shirian S., Sarkoohi P. Regulation of adiponectin gene expression in adipose tissue by thyroid hormones. J. Physiol. Biochem. 2012;68(2): 193-203.
  47. Altinova A.E., Törüner F.B., Aktürk M., Bukan N., Cakir N., Ayvaz G., Arslan M. Adiponectin levels and cardiovascular risk factors in hypothyroidism and hyperthyroidism. Clin. Endocrinol. (Oxf). 2006;65(4):530-35.
  48. Caixàs A., Tirado R., Vendrell J., et al. Plasma visfatin concentrations increase in both hyper and hypothyroid subjects after normalization of thyroid function and are not related to insulin resistance, anthropometric or inflammatory parameters. Clin. Endocrinol. (Oxf). 2009;71(5):733-38.
  49. Caixàs A., Tirado R., Vendrell J., Gallart L., Megla A., Simón I., Llauradó G., González-Clemente J.M., Giménez-Palop O. Plasma levels of adiponectin and soluble thrombomodulin in hypothyroid patients with normal thyroid function following levothyroxine replacement therapy. Biomed. Pharmacother. 2005;59(10): 571-77.
  50. Капралова И.Ю. Показатели липидного профиля и функциональное состояние миокарда у женщин с гипотиреозом. Эндокринология: новости, мнения, обучение. 2014;2:60-3.
  51. Yu H., Yang Y., Zhang M., Lu H., Zhang J., Wang H., Cianflone K. Thyroid status influence on adiponectin, acylation stimulating protein (ASP) and complement C3 in hyperthyroid and hypothyroid subjects. Nutr. Metab. (Lond). 2006;3(13).

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2017 Bionika Media

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies