CLINICAL RELEVANCE OF THE DETERMINATION OF SURFACTANT PROTEIN A AND D IN ASSESSMENT OF ACTIVITY OF PULMONARY SARCOIDIDOSIS


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Abstract

The article presents the results of a clinical study showing the clinical relevance of surfactant proteins A and D in the evaluation of the activity and progression of chronic pulmonary sarcoidosis. 41 patients with morphologically confirmed chronic sarcoidosis with signs of disease activity were examined. Chest high-resolution multispiral computed tomography, evaluation of diffusing lung capacity, and determination of oxygen saturation by pulse oximetry were performed. Serum surfactant protein SP-A and SP-D levels by enzyme-linked immunosorbent assay, as well as angiotensin-converting enzyme (ACE) activity were determined. Conclusions: 1 ) In patients with active chronic pulmonary sarcoidosis, a significant increase in the SP-A and, SP-D levels, and ACE activity in the phase compared to the control group was observed (p<0.001 ). 2) The increase in the SP-A levels correlates with the radiologic «frosted glass» symptom reflecting the stage of the alveolitis (p<0.05). 3) With the progression of pulmonary fibrosis to more than 20% of the pulmonary tissue area, an increase in the SP-D levels is observed (p<0.05). 4) ACE activity does not correlate with x-ray phenomena reflecting alveolitis (p>0.05) and progressive pulmonary fibrosis (p>0.05).

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About the authors

V. D Beketov

FSAEI HE I.M. Sechenov First Moscow State Medical University MHRF (Sechenov University)

Email: beketov-vladimir@inbox.ru
Assistant professor, Chair of Internal, Occupational Medicine and Pulmonology, The Faculty of Preventive Medicine

M. V Lebedeva

FSAEI HE I.M. Sechenov First Moscow State Medical University MHRF (Sechenov University)

N. A Mukhin

FSAEI HE I.M. Sechenov First Moscow State Medical University MHRF (Sechenov University)

E. N Popova

FSAEI HE I.M. Sechenov First Moscow State Medical University MHRF (Sechenov University)

A. G Serova

FSAEI HE I.M. Sechenov First Moscow State Medical University MHRF (Sechenov University)

V. A Solomka

FSAEI HE I.M. Sechenov First Moscow State Medical University MHRF (Sechenov University)

A. V. Kondrashov

FSAEI HE I.M. Sechenov First Moscow State Medical University MHRF (Sechenov University)

A. B Ponomarev

FSAEI HE I.M. Sechenov First Moscow State Medical University MHRF (Sechenov University)

M. Yu Brovko

FSAEI HE I.M. Sechenov First Moscow State Medical University MHRF (Sechenov University)

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